Genetic architecture of mammographic density as a risk factor for breast cancer: a systematic review.

Background: Mammography Density (MD) is a potential risk marker that is influenced by genetic polymorphisms and can subsequently modulate the risk of breast cancer. This qualitative systematic review summarizes the genes and biological pathways involved in breast density and discusses the potential clinical implications in view of the genetic risk profile for breast density.

Methods: The terms related to "Common genetic variations" and "Breast density" were searched in Scopus, PubMed, and Web of Science databases.