Publications by authors named "Mahboobul Hussain"
Article Synopsis
- Chloroquine (CQ) has been studied as a potential treatment for cancer, specifically colorectal cancer, by examining its effects on HCT-116 cells and its mechanism of action.
- CQ was found to inhibit the growth and survival of these cancer cells under hypoxic conditions by reducing both glycolytic capacity and NAD production through the inhibition of the PDK1 protein.
- The study revealed that CQ induces structural changes in PDK1, leading to its destabilization and increased degradation, which subsequently causes mitochondrial damage, excessive ROS production, and eventually triggers apoptosis in cancer cells.
This study describes identification of p16(INK4A) sequence variants and their potential association with esophageal squamous cell carcinoma (ESCC) in a high risk population from Kashmir, India. We report a novel 7 base pair exon 2 deletion in 22 out of 106 (~20%) surgically resected tumor samples. The deletion beginning at the second base of codon 103, results in a frame shift causing premature termination of the protein at codon 142, with structural and functional consequences predicted by insilico analysis.
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