Publications by authors named "Mahboobeh Shirazi"

Multiple placental cysts are a common finding in obstetric ultrasound imaging. Although they have benign differential diagnoses, such as hydropic degeneration of the placenta or placental mesenchymal dysplasia, it's important to consider significant pathologies, such as benign gestational trophoblastic disease or hydatidiform mole. A challenging issue in obstetrics is pregnancies with a placenta that has a bipartite texture.

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Early detection of fetal intracranial hemorrhage and infarct during pregnancy is crucial for preventing lethal and debilitating complications in neonatal life. Every radiologist must be aware of the imaging features of these conditions to refer patients to specialists. Sonographic and MRI features of fetal intracranial hemorrhage and infarct have been discussed in many previous articles.

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Fetal hemolysis is caused by maternal antibodies that cross the placenta. Anti-M antibodies can rarely cause severe forms of alloimmunization in the fetus and newborn. We present a case of severe anti-M alloimmunization requiring a total of 8 intrauterine transfusions, in a patient with a prior poor obstetrical history.

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Article Synopsis
  • A study looked at how to find out why some babies are born with problems, known as congenital anomalies (CAs), especially in families where cousins marry.
  • They tested different methods on 168 kids with CAs, finding that a method called exome sequencing (ES) worked better than another method called chromosomal microarray analysis (CMA) for families where cousins marry.
  • The results suggest that using ES first can help doctors discover these problems more effectively in those families.
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Background: Although the association between first-trimester increased nuchal translucency (NT) and chromosomal defects is well-defined, there is little knowledge about the importance of increased NT in fetuses with normal karyotypes. Hence, this study was designed to evaluate outcomes of normal karyotype fetuses with increased NT.

Methods: This observational retrospective study was conducted on 720 pregnancies with increased NT (>3mm) at 11 to 13 weeks of gestational age in Yas Hospital, Tehran, Iran, from 2016 to 2020.

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Twin reversed arterial perfusion (TRAP) sequence or acardiac twin is a rare and severe complication of monochorionic multiple pregnancies. Acardiac twin accounts for 10% of all TRAP sequences, which is the most morphologically developed acardius. We present an undiagnosed TRAP sequence case up to 24 weeks of gestation who underwent successful amnioreduction, radiofrequency ablation (RFA), and intrauterine transfusion (IUT).

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Objective: This study was conducted for determining pregnancy outcome after selective fetal reduction in twin pregnancies based on the gestational age at the time of the procedure in a referral academic center between 2017 and 2021.

Materials And Methods: This retrospective cohort study included all women with twin pregnancies who were diagnosed with a genetic or structural anomaly of one fetus or a desire to reduce the number of fetuses in order to reduce pregnancy complications visited in the period of 2017-2021. Reduction was performed due to an abdominal approach at 11 to 23 weeks of pregnancy.

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Rationale And Objectives: Monochorionic pregnancies are responsible for some severe complications, and selective reduction of a single fetus can improve pregnancy outcomes. This study evaluated the fetal outcomes and procedure-related prognostic factors after radiofrequency ablation (RFA) in complicated monochorionic multiple pregnancies.

Materials And Methods: This prospective cross-sectional study was conducted in an academic center from June 2020 to January 2022.

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Article Synopsis
  • The study aimed to develop diagnostic models using placental MRI parameters to identify intrauterine growth restriction (IUGR) and assess placental insufficiency severity.
  • It included 44 fetuses with appropriate weight and 46 with documented IUGR, categorizing them into severe and non-severe cases based on ultrasound Doppler criteria.
  • Results showed that specific MRI parameters effectively distinguished IUGR from appropriate weight cases and provided a good accuracy in predicting severity, indicating the potential of MRI in assessing fetal health.
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Background: Fetal exposure to maternal anxiety is associated with low birth weight and maternal stress may be led to constriction of uterine arteries. This study compared the relation of anxiety and uterine artery doppler flow indices in pregnant women with the high and low-risk of Down syndrome.

Materials And Methods: This prospective cohort study was conducted among pregnant women in the second trimester that were classified as having a high or low risk according to their prenatal aneuploidy screening outcome.

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Background: The cerebroplacental ratio (CPR) is an important factor for predicting adverse neonatal outcomes in appropriate-for-gestational-age fetuses.

Objective: To evaluate whether there is an association between the CPR level and adverse neonatal outcomes in appropriate-for-gestational-age fetuses.

Materials And Methods: This cross-sectional study included 150 low-risk pregnant women candidates for elective cesarean sections at the gestational age of 39 wk.

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Article Synopsis
  • The study investigated the prenatal and neonatal outcomes of monochorionic twins with fetal growth restriction (sFGR) and those with both sFGR and twin-to-twin transfusion syndrome (TTTS) after undergoing radiofrequency ablation (RFA).
  • Conducted from 2016 to 2020, the study analyzed various maternal and fetal data from 213 cases, utilizing statistical tests to compare outcomes between the two groups.
  • The results showed no significant differences in several key outcomes, including maternal age, delivery methods, and neonatal conditions, indicating that both groups had similar outcomes post-RFA despite earlier expectations of worse outcomes for the TTTS+sFGR group.
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Background: Despite technological advancements in perinatal imaging, autopsy examination is still regarded as the reference standard to determine the time and reason of the fetal death.

Purpose: This study was conducted to identify the intrauterine postmortem magnetic resonance imaging (PMMR) findings of fetuses, who underwent radiofrequency ablation (RFA).

Study Type: Prospective.

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Background: This study aimed to investigate the additional advantages of magnetic resonance imaging (MRI), particularly diffusion-weighted imaging (DWI) over fetal ultrasound in the detection of acute ischemic cerebral injuries in complicated monochorionic (MC) pregnancies that underwent selective reduction by radiofrequency ablation (RFA).

Methods: This prospective cohort study was conducted on 40 women with complicated MC pregnancies who were treated by RFA. Fetal brain imaging by DWI and conventional MRI was performed either in the early (within 10 days after RFA) or late phase (after 3-6 weeks) in the surviving fetuses to detect both acute and chronic ischemic injuries.

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Article Synopsis
  • - The corpus callosum (CC) is a crucial brain structure that connects the two hemispheres, and its abnormalities can range from agenesis (absence) to hypoplasia (underdevelopment) and hyperplasia (overdevelopment).
  • - CC anomalies are often associated with other defects in the central and peripheral nervous systems, making diagnosis complex.
  • - Ultrasound (US) can reliably detect complete CC agenesis after the mid-trimester, with specific signs like the lack of the cavum septum pellucidum and colpocephaly, while more subtle issues like hypoplasia can also be identified using US and magnetic resonance imaging (MRI).
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Predicting late-onset foetal growth restriction (FGR) has proven to be rather challenging. In this study, we propose a new parameter, cerebral-placental-uterine (CPU) ratio and umbilico-cerebral (UC) ratio for this matter. Results of this study which included a total of 227 nulliparous women showed that an increase in CPU ratio (OR = 0.

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Background: Selective reduction of the fetus is one of the therapeutic methods in complicated monochorionic twins. The present study aimed to investigate the success rate and perinatal outcomes of selective reduction using radiofrequency ablation (RFA) in monochorionic multiple pregnancies with a hydropic fetus.

Methods: This prospective interventional single-arm study was conducted in a referral hospital from 2017 to 2019.

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Purpose: To compare lung volume, lung apparent diffusion coefficient (ADC) and signal intensity ratio (SIR) on different magnetic resonance imaging (MRI) sequences between intrauterine growth restriction (IUGR) fetuses and the control group.

Materials And Methods: 49 IUGR and 58 non-IUGR fetuses were imaged using 3 Tesla MRI units. Total lung volume (TLV), lung/liver SIR (LLSIR) and lung/muscle SIR (LMSIR) in T1 and T2-weighted sequences and lung/liver ADC ratio (LLADCR) and lung/muscle ADC ratio (LMADCR) were assessed.

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Objective: This systematic review and meta-analysis aimed to compare the perinatal outcomes of complicated monochorionic pregnancies after selective reduction by radiofrequency ablation, bipolar cord coagulation, and interstitial laser.

Data Sources: We searched PubMed, Scopus, and Web of Science, from the inception of the database up to April 26, 2021.

Study Eligibility Criteria: Studies comparing at least 2 selective reduction techniques among complicated monochorionic pregnancies and presenting data on perinatal outcomes, including gestational age at procedure, gestational age at delivery, procedure to delivery interval, preterm premature rupture of membranes, preterm birth, survival rate, and birthweight, were eligible.

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High-level toxic metal exposure has become rare in the recent years. Although, it has not known whether relatively lower exposure may adversely affect human reproductive system. Spontaneous abortion (SA) is a serious reproductive problem, which, in many cases, the cause(s) is not clearly understood.

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Volvulus appears with unusual symptoms in pregnancy and postpartum, and if the clinicians do not consider it, the patient becomes complicated quickly. It seems that volvulus may cause obstetrics complications such as preterm delivery.

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Introduction: Inappropriate request for laboratory tests is a challenging problem and an important cause for additional healthcare costs. Indeed, it may have further ambiguity for the clinicians. This study aimed to design an education-based program to reduce unnecessary laboratory testing orders and the associated costs.

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Background: To evaluate the perinatal outcomes in women with complicated monochorionic diamniotic twins who underwent selective reduction using radiofrequency ablation (RFA).

Methods: This retrospective study included patients with complicated monochorionic diamniotic twins between 16 to 28 weeks who underwent selective reduction using RFA.

Results: During the study period, 143 women with complicated monochorionic twins underwent RFA including 52 with selective fetal growth restriction (sFGR), 48 with twin to twin transfusion syndrome (TTTS), 33 with major fetal anomalies in one of the twins, and 10 with reversed arterial perfusion sequence (TRAP).

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