Publications by authors named "Mahboobeh Pootari"
Article Synopsis
- Oxidative stress plays a key role in delayed graft function (DGF) following kidney transplantation, and glutathione S-transferases (GSTs) are genes that produce enzymes that help combat this stress.
- A study of 182 donor-recipient pairs found that higher lipid peroxidation levels correlated with DGF, and recipients with the GSTM1 null variant had a greater risk of DGF.
- The findings indicate that both donor and recipient GSTM1 polymorphisms are significant risk factors for oxidative stress, which negatively impacts kidney transplant outcomes.
Introduction: This study evaluated the influence of interleukin-10 (IL10) gene -1082G>A and tumor necrosis factor-alpha (TNF) gene -308G>A polymorphisms in the donor and recipients on the acute rejection (AR) episodes and delayed graft function (DGF) in kidney transplant recipients.
Materials And Methods: The IL10 -1082G>A and TNF -308G>A polymorphisms were determined in 100 kidney allograft recipients and their donors using the polymerase chain reaction-amplification refractory mutation system polymerase chain reaction-restriction fragment length polymorphism methods. Transplantation outcomes were determined in terms of AR and DGF criteria.