Modulatory Effects of Memantine on Neuronal Response Properties in Rat Barrel Cortex.

Introduction: Memantine as N-Methyl-D-Aspartic Acid (NMDA) receptor antagonist is used in some neurological disorders. Moreover, memantine presents modulatory effects on the somatosensory information processing in healthy subjects. This study investigated the effects of memantine on electrophysiological properties of barrel cortex neurons in male rats.

The role of transient receptor potential vanilloid type 1 in unimodal and multimodal object recognition task in rats.

Background: The role of transient receptor potential vanilloid type 1 (TRPV1) channels in learning and memory processes has recently been recognized. In the present study, the role of this receptor in the multisensory integration process was investigated.

Methods: This study was done using 96 male Wistar rats, which were kept in a reverse 12-12h dark/light cycle.