In accordance with the importance of telomerase inhibition as a potential target in cancer therapy, and increasing reports on the association between short telomeres and severe COVID-19 symptoms as well as extensive application of as a remedy for both cancer and SARS-CoV-2, the present study aimed at investigating the impact of the plant's extracts on telomerase activity (as an important enzyme regulating telomere length). Telomerase inhibition in MCF-7 cells treated with the Dichloromethane, ethanol, water, and methanol extracts of was assessed using Telomerase Repeated Amplification Protocol (TRAP). The above-mentioned extracts inhibited telomerase by 80.
View Article and Find Full Text PDFis a photosynthetic filamentous, edible cyanobacterium that is known as a superfood. In this study, sapogenins were extracted from the and the effects of these compounds on telomerase activity were evaluated in MCF7 and HDF cell lines using Telomeric Repeat Amplification Protocol and ELIZA assay. The highest increase in telomerase activity was observed at 0.
View Article and Find Full Text PDFAvicenna J Med Biotechnol
January 2017
Background: Biofilm infections are a major challenge in medical practice. Bacteria that live in a biofilm phenotype are more resistant to both antimicrobial therapy and host immune responses compared to their planktonic counterparts. So, there is need for new therapeutic strategies to combat these infections.
View Article and Find Full Text PDFBackground: A promising approach to kill antibiotic-resistant bacteria uses light in combination with a photosensitizer to induce a phototoxic reaction. A major concern with the use of any non-antibiotic antimicrobial treatment is that exposure of bacteria to sub-lethal concentrations will lead to the development of resistance to antibiotics. This study aimed to determine the effect of sub-lethal photodynamic inactivation (PDI) on the antibiotic susceptibility and biofilm formation of clinical Staphylococcus aureus isolates.
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