Cholesterol-terminated cationic lipidated oligomers (CLOs) as a new class of antifungals.

Infections caused by fungal pathogens are a global health problem, and have created an urgent need for new antimicrobial strategies. This report details the synthesis of lipidated 2-vinyl-4,4-dimethyl-5-oxazolone (VDM) oligomers an optimized Cu(0)-mediated reversible-deactivation radical polymerization (RDRP) approach. Cholesterol-Br was used as an initiator to synthesize a library of oligo-VDM (degree of polymerisation = 5, 10, 15, 20, and 25), with an α-terminal cholesterol group.

Predictors of the willingness to accept a free COVID-19 vaccine among households in Nigeria.

Background: To inform vaccination policy and programmatic strategies to increase COVID-19 vaccine uptake, an understanding of the factors associated with the willingness to vaccinate is needed.

Methods: We analyzed data collected from the sixth and tenth round of the Nigerian COVID-19 National Longitudinal Phone Survey conducted by the National Bureau of Statistics and the World Bank in 2020 and 2021, respectively. Exploratory data analysis and feature selection techniques were used to identify important variables.

Providing insight into the mechanism of action of cationic lipidated oligomers using metabolomics.

The increasing resistance of clinically relevant microbes against current commercially available antimicrobials underpins the urgent need for alternative and novel treatment strategies. Cationic lipidated oligomers (CLOs) are innovative alternatives to antimicrobial peptides and have reported antimicrobial potential. An understanding of their antimicrobial mechanism of action is required to rationally design future treatment strategies for CLOs, either in monotherapy or synergistic combinations.

Massive left pulmonary artery aneurysm with a co-existing patent ductus arteriosus in a five-year-old female child: A case report.

Pulmonary Artery Aneur ysm (PAA), whether congenital or acquired, is a rare diagnostic find ing com pare d to aor tic aneur ysms. There have been fe w cases where PA As were documented as a complication of untreated Patent Ductus Ar teriosus (PDA) due to long-standing Pulmonary Arterial H ypertension (PAH). However, it is quite rare for a case of PAA to be reported with co-existing PDA without PAH.

Influence of °Brix/Acid, and flow rate of pineapple juice and electric field strength on the performance of continuous ohmic heating system.

Unlabelled: A lab-scale continuous ohmic heating (COH) system was developed, and its performance was studied for pineapple juice heating as a model sample. The effect of independent parameters [°Brix/Acid (unstandardized, 18, 22, 26) and flow rate (80-120 mL/min) of juice and electric field strength (EFS: 25-45 V/cm)] were analysed for responses viz. come-up-time, heating rate (HR) and system performance coefficient (SPC).

An integrated remediation approach using combinations of biochar, , and for immobilizing and dissipating cadmium contaminants from the soil-mustard plant system.

Cadmium (Cd) contamination of soils is an environmental concern, as cadmium harms food crops and can therefore impact human health. The use of combinations of biochar (seeded with ) and (as an intercrop) has the potential to reduce the mobilization of Cd from soil mustard plants (). Mustard plants are grown as a food and oil production crop that is consumed worldwide.

The Burden of Surgical Site Infection at Hospital Universiti Sains Malaysia and Related Postoperative Outcomes: A Prospective Surveillance Study.

Surgical site infections (SSIs) are the most common healthcare-associated infections that occur among surgical patients. Surgical site infections result in longer hospital stays, hospital readmissions, and higher death and morbidity rates. The current study was designed to highlight the importance of such surveillance studies in a Malaysian surgical population with a motive to evaluate and revise concurrent infection control and prevention policies by exploring the burden of surgical site infection and identifying its associated risk factors for future considerations.

A new isolate of (Bütschli, 1873) Dougherty, 1955 (Rhabditida: Rhabditidae): re-evaluated with molecular data and scanning electron microscopic observations.

A new isolate of (Bütschli, ) Dougherty, is described and illustrated with morphological and molecular data. The phylogenetic analysis based on the D2/D3 segment of 28S rDNA using the Bayesian inference method, revealed monophyly of the genus as the subordinate taxa clustered in one clade. The clade further divided into two subclades representing the group and group with 100% posterior probability values.

Comparison Of Topical 0.1% Adapalene Gel Versus Cryotherapy In Patients With Plantar Warts.

Background: Plantar wart is a common viral infection of the plantar surface of the foot. Multiple treatment modalities are available but there is no definitive management option. The aim of this study is to compare topical adapalene gel 0.

Molecular and phenotypic characterization of two cryptic species of the predatory genus Rahm, 1928 (Rhabditida: Diplogastridae) and their congeneric affinities.

Based on morphometric, morphological and molecular characterization using partial small subunit 18S ribosomal DNA (rDNA) and the D2/D3 domain of large subunit 28S rDNA, we described a new species collected from manure, and the known species Steel, Moens, Scholaert, Boshoff, Houthoofd and Bert, 2011, isolated from the dung beetle (Fabricius, 1775). Phylogenetic trees based on the evolutionary model (GTR + I + G) were inferred by Bayesian inference algorithms. sp.

NUMERICAL EVALUATION OF SPECIFIC ABSORPTION RATE IN HUMAN HEAD AND TORSO FOR WEARABLE WIRELESS DEVICES IN UNDERGROUND MINE SCENARIOS.

The radiofrequency field levels may increase in confined environments, such as underground mines, due to reflections from inner boundaries (walls and arches). This study investigated the specific absorption rate (SAR) in the head and torso of a miner wearing a wireless device in underground mine scenarios. Two high-resolution voxel models were used to analyse the effects of a tunnel structure, a metal arch and a safety helmet at 2.

Seldinger chest drain guidewire retained in the pleural cavity-a never event complication.

Intrapleural foreign body is an unusual complication. It most commonly occurs after the trauma but has been rarely seen after diagnostic or therapeutic procedures. We hereby, present an unusual occurrence of a retained guidewire after a chest drain insertion using a Seldinger technique in a patient with coronavirus disease of 2019 pneumonitis.

Molecular phylogeny and new insight into the stomatal complexity of sp. n. (Diplogastridae: Nematoda) associated with (Coleoptera: Scarabaeidae).

The new species Fictor platypapillata was isolated from dung beetle Oniticellus cinctus (Scarabaeidae), collected from the district Balrampur, Uttar Pradesh, India. Fictor platypapillata sp. n.

The Modulation of Water, Nitrogen, and Phosphorous Supply for Growth Optimization of the Evergreen Shrubs for Revegetation Purpose.

Surface mining is a critical anthropogenic activity that significantly alters the ecosystem. Revegetation practices are largely utilized to compensate for these detrimental impacts of surface mining. In this study, we investigated the effects of five water (W) regimes [W: 40%, W: 48%, W: 60%, W: 72%, and W: 80% of field capacity (FC)], five nitrogen (N) (N: 0, N: 24, N: 60, N: 96, and N: 120 mg kg soil), and five phosphorus (P) fertilizer doses (P: 0, P: 36, P: 90, P: 144, and P: 180 mg kg soil) on morpho-physiological and biochemical parameters of plants to assess the capability of this species to be used for restoration purposes.

Outcomes of islanded scrotal raphe flap employment for skin shortage in complicated hypospadias repair.

Background: Ventral skin deficiency in complicated hypospadias is a difficult problem to treat. The aim of our study is to report our technique and outcomes of vascularized islanded scrotal raphe flap for ventral skin deficiency in complicated hypospadias.

Methods: A retrospective review was conducted at Northwest General Hospital & Research Centre, Peshawar, from January 2012 to January 2019.

Plant growth promoting and antifungal asset of indigenous rhizobacteria secluded from saffron (Crocus sativus L.) rhizosphere.

Saffron (Crocus sativus L.) is an important plant in medicine. The Kashmir Valley (J&K, India) is one of the world's largest and finest saffron producing regions.

A unified approach to design controller in cascade control structure for unstable, integrating and stable processes.

This article presents a unified approach of controller design in cascade control structure (CCS) for unstable, integrating and stable processes with dead-time to achieve enhanced load disturbance rejection. The design of inner and outer loop controllers in CCS is based, partially on the direct synthesis approach and partially on the pole placement method. First, the parameters of the inner loop controller are obtained and then the outer loop controller is designed by considering the inner loop as a part of the primary plant.

A detailed taxonomic study on two new and one known species of Anaplectus De Coninck Schuurmans Stekhoven, 1933 (Nematoda: Plectidae).

This paper provides descriptions of two new and one known species of the genus Anaplectus De Coninck Schuurmans Stekhoven, 1933. Anaplectus sudhausi sp. nov.

effects of cobalt nanoparticles on aspartate aminotransferase and alanine aminotransferase activities of wistar rats.

Cobalt nanoparticles (Co-NPs) have been extensively used in clinical practices and medical diagnosis. In this study, the potential toxicity effects of Co-NPs with special emphasis over the biochemical enzyme activities, such as aspartate aminotransferase (ASAT) and alanine aminotransferase (ALAT) in serum, liver, and kidney of Wistar rats were investigated. This toxicity measurement of nanomaterials can support the toxicological data.

Protective effect of Yemeni green coffee powder against the oxidative stress induced by Ochratoxin A.

The current study focusses on knowing the antioxidant effects of green Yemeni coffee powder on reducing the oxidative stress that was induced by Ochratoxin A in kidney, liver and brain of rats. The grouping of female albino Wistar rats was into 5 groups (5 rats/group). Rats of Group 1 designated Vehicle Control (only water), Group2 (10 mg/kg Ochratoxin A); Group 3 designated Low dose (2000 mg/kg Coffee+10 mg/kg Ochratoxin A); Group 4 designated High dose (4000 mg/kg Coffee+10 mg/kg Ochratoxin A); Group 5 designated Coffee Control (1000 mg/kg Coffee) and orally administered with the above test materials repeatedly every day for 28 days.

Rhynchosia rufescens AgNPs enhance cytotoxicity by ROS-mediated apoptosis in MCF-7 cell lines.

The present study deals with the synthesis of silver nanoparticles (AgNPs) from Rhynchosia rufescens and to evaluate its cytotoxic effect mediated through induced apoptosis. The reduction and capping of phytoconstituents was confirmed using FTIR demonstrating O-H and C-H stretching at different peaks. The size and the shape of the particle were determined using scanning electron microscopy (SEM) illustrating 1 μm to 100 nm in size and the composition of compounds in the AgNPs were revealed using XRD and EDX.