Novel azole-sulfonamide conjugates as potential antimicrobial candidates: synthesis and biological assessment.

Azole and sulfonamide molecular frameworks are endowed with potent antimicrobial activity. A series of azole-sulfonamide conjugates were synthesized using click reaction of N-propargylated imidazole with azide of sulfonamide and its antimicrobial efficacy was evaluated. The compounds , and displayed promising antibacterial activities, better than the standards sulfonamide and norfloxacin.

An Introductory Overview on Applications of Pyrazoles as Transition Metal Chemosensors.

Utility of pyrazoles and their derivatives in constructing ordered porous materials with physicochemical characteristics such as chemosensors has undoubtedly created much interest in developing newer frameworks. A variety of pyrazole based chemosensors are known for their remarkable photophysical, pH sensitivity, solvatochromic, ion detection, high quantum yields and nonlinear optical behavior. Many of the transition metals have shown beneficial biological effects in biological systems.