Deacylative Homolysis of Ketone C(sp)-C(sp) Bonds: Streamlining Natural Product Transformations.

The homolytic cleavage of C-C bonds adjacent to specific functional groups has lately emerged as a versatile approach for molecular diversification. Despite the ubiquity and synthetic utility of ketones, radical fragmentation of their α-C-C bonds has proven to be a formidable challenge. Here, we present a broadly applicable deacylative strategy designed to homolytically cleave aliphatic ketones of various complexities, including transformations of cycloalkanones into carboxylic acids tethered to C-centered free radicals that can be engaged in diverse radical-based processes.

Investigating the formation of metal nitride complexes employing a tetradentate bis-carbene bis-phenolate ligand.

The synthesis of Mn and Cr nitride complexes of a pro-radical tetradentate bis-phenol bis-N-heterocyclic carbene ligand H2LC2O2 was investigated. Employing either azide photolysis of the Mn precursor complex MnLC2O2(N3) or a nitride exchange reaction between MnLC2O2(Br) and the nitride exchange reagent Mnsalen(N) failed to provide a useful route to the target nitride MnLC2O2(N). Experimental results support initial formation of the target nitride MnLC2O2(N), however, the nitride rapidly inserts into a Mn-C bond.

Proximity labeling reveals interactions necessary to maintain the distinct apical domains of Drosophila photoreceptors.

Specialized membrane and cortical protein regions are common features of cells and are utilized to isolate differential cellular functions. In Drosophila photoreceptors, the apical membrane domain is defined by two distinct morphological membranes: the rhabdomere microvilli and the stalk membrane. To define the apical cortical protein complexes, we performed proximity labeling screens utilizing the rhabdomeric-specific protein PIP82 as bait.

Synergistic effects of Fe and Ag doping on the structural and optical properties of a TiO thin film: a dual function platform for hydrogen generation and dye degradation.

The global population is increasing at an alarming pace, leading to a rapid surge in industrialization and concomitant environmental degradation. In light of the present circumstances, it is crucial to find sustainable solutions to mitigate pollution and ensure a safe and clean environment for the present and future society. One promising solution is photocatalysis, which utilizes solar energy to address environmental issues while providing a renewable and sustainable energy source.

Reply to the Correspondence on "Visible Light-Switchable Chalcone-Flavylium Photochromic Systems in Aqueous Media".

In a Correspondence on our previous work, "Visible light-switchable chalcone flavylium photochromic systems in aqueous media" published in this journal in 2023, Pina et al. comment on certain aspects of our work, raising skepticism and questions about the switching of the chalcone-flavylium systems. We appreciate their comments and acknowledge the remarkable contribution of Pina and co-workers in this field.

Light-induced reversible switching of generation and extinction of an organic radical anion.

Radicals play a crucial role across various domains, ranging from serving as catalysts in chemical reactions to materials for spintronic applications. Currently, a major challenge for the chemists is the development of the next generation of organic radicals controllable by photons. To tackle this challenge, here we introduce a dyad system that combines a dimethyldihydropyrene (DHP) photochromic unit with a naphthalene diimide (NDI) moiety.

Alkoxide-Assisted Stereoselective Functionalization of 1,2-Bis-boronic Esters Under Photoredox Catalysis.

Site-specific functionalization of the secondary C-B bond of 1,2-bis-boronic esters has been proven to be an important method for the generation of 1,2-bis-functionalized compounds in a highly stereoselective manner. We have explored previously unknown secondary selective alkenylation, allylation, alkynylation and addition to aryl vinyl trifluoromethane, which proceeds via a novel reaction mechanism: alkoxide-mediated photoredox activation to generate secondary radicals over the primary one.

PAM-flexible Engineered FnCas9 variants for robust and ultra-precise genome editing and diagnostics.

The clinical success of CRISPR therapies hinges on the safety and efficacy of Cas proteins. The Cas9 from Francisella novicida (FnCas9) is highly precise, with a negligible affinity for mismatched substrates, but its low cellular targeting efficiency limits therapeutic use. Here, we rationally engineer the protein to develop enhanced FnCas9 (enFnCas9) variants and broaden their accessibility across human genomic sites by ~3.

Generation and characterization of a Stargardt's disease-specific induced pluripotent stem cell line (LVPEIi008-A) with a homozygous nonsense mutation in exon 44 of ABCA4.

The Stargardt's Disease, Type 1 (STGD1) is associated with the loss of function mutations in ABCA4. This gene codes for a retina-specific, ATP-binding cassette (ABC) family transporter, involved in the transport of the key visual cycle intermediate, all-trans-retinaldehyde (atRAL), across the photoreceptor cell membranes. Here, we report the establishment of a patient-specific, iPSC line (LVPEIi008-A), that carries a homozygous nonsense mutation at (c.

Effect of Dual-Organic Cations on the Structure and Properties of 2D Hybrid Perovskites as Scintillators.

Two-dimensional (2D) hybrid organic-inorganic perovskite (HOIP) crystals show promise as scintillating materials for wide-energy radiation detection, outperforming their three-dimensional counterparts. In this study, we synthesized single crystals of (PEABZA)PbBr ( ranging from 0.1 to 2), utilizing phenethylammonium (CHCHCHNH) and benzylammonium (CHCHNH) cations.

Generation of two induced pluripotent stem cell lines (LVPEIi004-A and LVPEIi005-A) from probands with Leber Congenital Amaurosis 2 (LCA2) and harboring mutations in RPE65.

Leber Congenital Amaurosis 2 is an early onset retinal dystrophy that occurs due to mutation in RPE65 gene. Here, we report the generation of two patient specific induced pluripotent stem cell lines harboring nonsense mutations in exon 7 (c.646A > T) and exon 9 (c.

Generation of two induced pluripotent stem cell lines (LVPEIi007-B, LVPEIi008-B) from patients harboring homozygous mutation in ABCA4 (c.6088C>T) using non-integrative Sendai virus-based approach.

Mutations in ABCA4 gene leads to the most common form of an inherited retinal disease namely, the Stargardt disease, type 1. Here, we report the generation of two different patient-specific induced pluripotent stem cell lines (LVPEIi007-B and LVPEIi008-B), carrying an identical homozygous mutation, (c.6088C>T) within the exon 44 of ABCA4 gene.

Improvement of Light Output of MAPbBr Single Crystal for Ultrafast and Bright Cryogenic Scintillator.

The remarkable brightness and rapid scintillation observed in perovskite single crystals (SCs) become even more striking when they are operated at cryogenic temperatures. In this study, we present advancements in enhancing the scintillation properties of methylammonium lead bromide (MAPbBr) SCs by optimizing the synthesis process. We successfully synthesized millimeter-sized MAPbBr SCs with bright green luminescence under UV light.

Unusually short unsupported Au(III)⋯Au(III) aurophilic contacts in emissive lanthanide tetracyanoaurate(III) complexes.

A series of [Au(CN)] salts with lanthanide 2,2'-bipyridine dioxide cations features Au(III) aurophilic interactions between [Au(CN)] groups, with Au⋯Au distances of 3.3603(4) Å and 3.4354(4) Å that are shorter than any previously reported.

Generation of Leber congenital amaurosis, type 12 patient-specific induced pluripotent stem cell line (LVPEIi006-A), harboring a homozygous mutation in RD3.

Leber congenital amaurosis (LCA) is a congenital, early onset, autosomal recessive inherited retinal disease (IRD). This report describes an LCA12 patient-specific iPSC line (LVPEIi006-A), generated by the reprogramming of dermal fibroblasts using integration-free episomal plasmids.This disease-specific iPSC model carries a homozygous point mutation in RD3, within the donor splice site at the end of exon 2 (c.

Neoadjuvant Peptide Receptor Radionuclide Therapy in a Rare Case of Pediatric Primary Hepatic Gastrinoma.

Gastrinomas with predilection for the adult male population are located in the gastrinoma triangle (>90%). Primary hepatic gastrinoma especially in pediatric population is very rare. Peptide receptor radionuclide therapy has shown benefit in metastatic gastroenteropancreatic neuroendocrine tumors (NETs) with an increasing interest in expanding its role as neoadjuvant treatment modality to improve the surgical candidature in inoperable NETs.

Untangling ancillary ligand donation locus of oxidation effects on metal nitride reactivity.

We detail the relative role of ancillary ligand electron-donating ability in comparison to the locus of oxidation (either metal or ligand) on the electrophilic reactivity of a series of oxidized Mn salen nitride complexes. The electron-donating ability of the ancillary salen ligand was tuned the -phenolate substituent (R = CF, H, Bu, OPr, NMe, NEt) in order to have minimal effect on the geometry at the metal center. Through a suite of experimental (electrochemistry, electron paramagnetic resonance spectroscopy, UV-vis-NIR spectroscopy) and theoretical (density functional theory) techniques, we have demonstrated that metal-based oxidation to [Mn(Sal)N] occurs for R = CF, H, Bu, OPr, while ligand radical formation to [Mn(Sal)N]˙ occurs with the more electron-donating substituents R = NMe, NEt.

Air pollution status and attributable health effects across the state of West Bengal, India, during 2016-2021.

Air pollution is one of the most significant threats to human safety due to its detrimental health consequences worldwide. This study examines the air pollution levels in 22 districts of West Bengal from 2016 to 2021, using data from 81 stations operated by the West Bengal Pollution Control Board (WBPCB). The study assesses the short- and long-term impacts of particulate matter (PM) on human health.