Publications by authors named "Maharnob Sarkar"
Article Synopsis
- MicroRNAs (miRNAs) are short RNA molecules that regulate gene expression by binding to target mRNA, and predicting their targets often leads to many potential candidates that require further study.
- This study used a method called SILAC-based proteomics to analyze protein expression changes caused by over-expressing specific miRNAs, miR-34a and miR-29a, resulting in the identification of proteins that might be involved in apoptosis.
- Although the study found some mitochondrial proteins as targets of miR-29a, the overall low number of identified proteins and challenges in distinguishing effects meant that miRNA-proteomics may not be the best high-throughput method for identifying miRNA targets, but it did offer insights into their
Nucleic Acids Res
October 2012
Article Synopsis
- Nucleosome positioning maps reveal that Transcription Start Sites (TSSs) are characterized by a lack of nucleosomes, surrounded by well-positioned nucleosomes in various organisms.
- In mouse liver, most genes contain a notable nucleosome with the histone variant H2A.Z in their promoter regions, and clustering of genes is observed based on H2A.Z's distance from the TSS.
- Genes lacking H2A.Z show lower expression, while those with H2A.Z closer to the TSS exhibit higher expression levels, indicating that TSS accessibility and H2A.Z proximity influence gene expression.
