Diabetes mellitus: Preventive and curative therapies with aqueous extract of Blume (Rubiaceae) in Wistar rats.

Background And Aim: African traditional healers use Blume to treat diseases such as diabetes mellitus, malaria, dysentery, constipation, and hemorrhoids. This study aimed to assess the hypoglycemic, lipid-lowering, and antioxidant properties of extract (AERS) in type 1 diabetic (T1D) and insulin-resistant (T2D) rats.

Experimental Procedure: The induction of T1D was made by intraperitoneal administration of streptozotocin (55 mg/kg b.

Glucose, lipid and oxidative stress lowering activity of the aqueous extract from leafy stems of Gilg & Brandt in dexamethasone-induced hyperglycemia in rats.

Background: Diabetes mellitus is a metabolic disorder characterised by chronic hyperglycemia. The present research work aimed to evaluate the hypoglycaemic, hypolipidemic and antioxidant effects of leafy stems of Gilg & Brandt in insulin resistant rats.

Methods: The oral glucose tolerance test (OGTT) was performed in normal rats.

Glucose-lowering potential of roots in a diabetic rat model.

Objective: is distributed in the Sudano-Sahelian zone and used traditionally for the treatment of diabetes. This study was designed to assess the hypoglycemic effects of in Wistar diabetic rats.

Materials And Methods: Phytochemical analysis was carried out on aqueous and methanolic extracts of .

Antioxidant Properties and Digestive Enzyme Inhibitory Activity of the Aqueous Extract from Leafy Stems of .

(Vitaceae) is a plant used in Cameroonian traditional medicine for the treatment of diabetes. The aims of this study were to evaluate the in vitro antioxidant and antidiabetic activities of the aqueous extract of leafy stems. The enzyme inhibitory activity was determined in vitro on -amylase and -glucosidase enzymes, followed by confirmative study in vivo on normal rats (oral starch and sucrose tolerance tests at doses of 111, 222, and 444 mg/kg).