Exploring the Electronic, Optical, and Charge Transfer Properties of A-D-A-Type IDTV-ThIC-Based Molecules To Enhance Photovoltaic Performance of Organic Solar Cells.

Improving the charge mobility and optoelectronic properties of indacenodithiophenebased small molecule acceptors is a key challenge to improving overall efficiency. In this current research, seven newly designed molecules () comprising the indacenodithiophenebased core are presented to tune energy levels, enhance charge mobility, and improve the photovoltaic performance of molecules via density functional theory. All the molecules were designed by end-capped modification by substituting terminal acceptors of with strong electron-withdrawing moieties.

Upadacitinib protects against cisplatin-induced renal and hepatic dysfunction without impairing its anticancer activity.

Cisplatin-induced renal and hepatic dysfunctions are major drawbacks and obstacles to its clinical applications. Induction of inflammation is a part of its molecular mechanism of toxicity. The impact of upadacitinib, a selective JAK1-inhibitory anti-inflammatory agent, on cisplatin-induced adverse effects, histopathologic changes, kidney and liver functions, oxidative stress, and inflammatory biomarkers were investigated compared to silymarin and losartan in male Wistar rats.