Antimicrobial gelatin-based films with cinnamaldehyde and ZnO nanoparticles for sustainable food packaging.

Cinnamaldehyde (CIN), a harmless bioactive chemical, is used in bio-based packaging films for its antibacterial and antioxidant properties. However, high amounts can change food flavor and odor. Thus, ZnO nanoparticles (NPs) as a supplementary antimicrobial agent are added to gelatin film with CIN.

Fabrication of multifunctional ZnO@tannic acid nanoparticles embedded in chitosan and polyvinyl alcohol blend packaging film.

The current study explores biodegradable packaging materials that have high food quality assurance, as food deterioration is mostly caused by UV degradation and oxidation, which can result in bad flavor and nutrition shortages. Thus, new multifunctional zinc oxide nanoparticles/tannic acid (ZnO@TA) with antioxidant and antibacterial activities were incorporated into polyvinyl alcohol/chitosan (PVA/CH) composite films with different ratios (1%, 3%, and 5% based on the total dry weight of the film) via a solution blending method in a neutral aqueous solution. Additionally, ZnO nanoparticles have unique antibacterial mechanisms through the generation of excessive reactive oxygen species (ROS) that may lead to intensify pathogen resistance to conventional antibacterial agents.

Sustained-release nitrogen fertilizer delivery systems based on carboxymethyl cellulose-grafted polyacrylamide: Swelling and release kinetics.

Sustained or controlled-release delivery systems can enhance functions such as nutrient usage; minimize soil contamination, and reduce the required fertilizer dose. This paper reports the development of a carboxymethyl cellulose-g-polyacrylamide copolymer (CMC-g-PAM) as a sustained and slow-release fertilizer carrier for urea. The developed copolymer was characterized by Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Scanning Electron Microscopy (SEM), and thermo gravimetric analysis (TG).

Dialdehyde cellulose/gelatin hydrogel as a packaging material for manganese oxides adsorbents for wastewater remediation: Characterization and performance evaluation.

The dialdehyde cellulose (DC) was used to synthesize gelatin-cellulose dialdehyde by Schiff base as a packaging material to manganese oxides nanoparticles adsorbents (Mn oxides@DC/Gel) for wastewater remediation and support the antimicrobial behavior of gelatin and DC. The crystallinity index% of microwave-synthesized DC prepared from cellulose II decreased from 43.18% to 34.

Fabrication and evaluation of antimicrobial cellulose/Arabic gum hydrogels as potential drug delivery vehicle.

This article aims to assess the highly potent antimicrobial hydrogels composed of cellulose and Arabic gum containing sulfadiazine drug (sulfadiazine-loaded Cel/AG) as drug-targeting carriers. ATR-IR, SEM/ EDS, XRD, and XPS methods were used to investigate the hydrogel. The highest water absorption % was 489.

Sensitive and effective electrochemical determination of butenafine in the presence of itraconazole using titanium nanoparticles-ionic liquid based nanocomposite sensor.

Unlabelled: The evaluation of the bioavailability of topically applied medications that act inside or under the skin is a challenging task. Herein, the current study describes a simple, quick, and low-cost electrochemical platform for determining butenafine hydrochloride (BTH) that is mainly prescribed as a treatment of dermatophytosis, applying titanium nanoparticles and an ionic liquid as outstanding mediators. In terms of low detection limits (61.

Smart edible coating films based on chitosan and beeswax-pollen grains for the postharvest preservation of Le Conte pear.

Smart edible coating films can be used in food packaging. For this application, they must have good physical and mechanical properties. Herein, chitosan-beeswax based film is used to preserve Le Conte pears postharvest.

Quality assessment of lemon (Citrus aurantifolia, swingle) coated with self-healed multilayer films based on chitosan/carboxymethyl cellulose under cold storage conditions.

The polyelectrolyte multilayer self-healing coating film of chitosan and carboxymethyl cellulose (PEM-SH) tended to maintain high sensory quality and control physiological and pathological decay of lemon fruits under cold storage. The PEM-SH film was characterized by ATR-IR, XRD, X-ray photoelectron spectroscopy, SEM analysis, swelling ratio, self-healing, and mechanical characteristics. The 3-layered film (3L) exhibited the optimum barrier properties; WVP: 3.

Physically-crosslinked hydroxyethyl cellulose-g-poly (acrylic acid-co-acrylamide)-Fe/silver nanoparticles for water disinfection and enhanced adsorption of basic methylene blue dye.

In this study, we report the development of physically cross-linked hydroxyethyl cellulose grafted polyacrylic acid-co-polyacrylamide/silver nanocomposite [Ag@HEC-g-P(AA-co-AM)-Fe] possesses excellent antimicrobial and enhanced MB adsorption. A green in-situ reduction process was used to prepare silver nanoparticles. UV-Vis spectroscopy, TEM, ATR-IR, XRD, SEM-EDS were used to analyze the green produced silver nanoparticles and Ag@HEC-g-P(AA-co-AM)-Fe.

Development of Arabic gum-based AgTiO nanocomposite hydrogel as high efficient adsorbent of cationic dye methylene blue from water.

The chemically crosslinked silver titanium dioxide embedded Arabic gum grafted polyacrylamide-polyacrylonitrile nanocomposite AgTiO@AG-g-P(AM-co-AN)was successfully synthesized and investigated by ATR-IR, XRD, and SEM. The synthesis optimization parameters of AG-g-P(AM-co-AN)were 5% AG, 1/0.5 AM/AN monomer molar ratio, 0.

Simultaneous determination of dantrolene and paracetamol in human plasma by liquid chromatography tandem mass spectrometry.

A simple, sensitive, rapid and specific method based on ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) for the simultaneous quantification of dantrolene (DAN) and paracetamol (PAR) in real human plasma was developed and validated. The preparation of sample was achieved by liquid-liquid extraction with tertiary butyl methyl ether. The analysis was performed on a reversed-phase Ccolumn (1.

Novel Application of Pentabromobenzyl Column for Simultaneous Determination of Eight Antifungal Drugs Using High-performance Liquid Chromatography.

Aim: A new, accurate and sensitive reversed-phase high-performance liquid chromatography (RP-HPLC) as an analytical method for the quantitative determination of eight antifungal drugs in spiked human plasma has been described optimized and validated.

Materials And Methods: The analyzed compounds were voriconazole (VOR), luliconazole (LUL), clotrimazole (CLO), tioconazole (TIO), posaconazole (POS), ketoconazole (KET), sertaconazole (SER) and terconazole (TER).

Results: The separation of the analyzed compounds was conducted using a novel pentabromobenzyl column known as COSMOSIL PBB-R (150 mm × 4.

Detection and quantification of warfarin in pharmaceutical dosage form and in spiked human plasma using surface enhanced Raman scattering.

Analytical approaches for the quantitation of warfarin in plasma are high in demand. In this study, a novel surface enhanced Raman scattering (SERS) technique for the quantification of the widely used anticoagulant warfarin sodium in pharmaceutical dosage form and in spiked human plasma was developed. The colloidal-based SERS measurements were carefully optimized considering the laser wavelength, the type of metal nanoparticles, their surface functionalization and concentration as well as the time required for warfarin to associate with the metal surface.

Development and validation of liquid chromatography-electrospray-tandem mass spectrometry method for determination of flibanserin in human plasma: Application to pharmacokinetic study on healthy female volunteers.

A novel rapid and highly sensitive ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) bioanalytical method was established for the analysis of flibanserin in human plasma. Flibanserin d4 was used as internal standard (IS). Flibanserin and the internal standard (IS) were extracted from the plasma using protein precipitation technique with acetonitrile.

Stability-indicating micellar enhanced spectro-fluorometric determination of Daclatasvir in its tablet and spiked human plasma.

A fast, simple and sensitive micellar enhanced spectrofluorimetric method is performed for the determination of Daclatasvir dihydrochloride (DAC) in its pharmaceutical dosage form and in spiked human plasma. The fluorescence intensity (FI) was measured at 367 nm after excitation at 300 nm. In aqueous solution, the FI of DAC was greatly enhanced by >110% in the presence of sodium dodecyl sulphate (SDS).

Optimized polydopamine coating and DNA conjugation onto gold nanorods for single nanoparticle bioaffinity measurements.

Gold nanorods (NRs) have attracted a great deal of interest for a variety of biomedical and sensing applications. However, developing robust methods for biofunctionalizing NRs has continued to be challenging, especially for NR-DNA conjugates. This is due to the presence of cetyltrimethylammonium bromide (CTAB), which plays an essential role in controlling the anisotropic particle growth.

Validated stability-indicating capillary electrophoresis method for the separation and determination of a fixed-dose combination of carvedilol and hydrochlorothiazide in tablets.

A novel, fast, sensitive, and specific capillary electrophoresis (CE) technique coupled to a diode array detector has been developed for the separation and simultaneous determination of carvedilol (CRV) and hydrochlorothiazide (HCT) in two combination formulations. The proposed method utilized a fused silica capillary (55 cm x75 microm id) and the background electrolyte solution phosphate buffer (12.5 mM, pH 7.

Analytical study for the charge-transfer complexes of rosuvastatin calcium with π-acceptors.

Studies were carried out to investigate the charge-transfer (CT) reaction of ROS-Ca, as a n-electron donor with various p-acceptors: tetracyanoethylene, p-chloranilic acid, 2,3-dichloro-5,6-dicyano-1,4-benzoquinone, 2,3,5,6-tetrabromo-1,4-benzoquinone, 1,3,5-trinitrobenzene, 2,3,5,6-tetrachloro-1,4-benzoquinone, 7,7,8,8-tetracyano-quinodimethane, and 2,4,7-trinitro-9-fluorenone. Different colored CT complexes were obtained. The reaction mechanism and site of interaction were determined by ultraviolet-visible spectrophotometric techniques and computational molecular modeling.

Capillary electrophoretic determination of antimigraine formulations containing caffeine, ergotamine, paracetamol and domperidone or metoclopramide.

A novel, fast, sensitive and specific technique using capillary electrophoresis coupled to a diode array detector has been developed for the separation and simultaneous determination of two antimigraine mixtures in tablet formulation. The two combinations are ergotamine tartrate (ERG), caffeine (CAF) and paracetamol (PAR) with either domperidone (DOM), combination (I) or metoclopramide (MET), combination (II). The proposed method utilized a fused silica capillary (55 cm × 75 µm i.

Inhibition of angiogenesis as a new therapeutic target in the treatment of lepromatous leprosy.

Background: Angiogenesis was suggested to have a significant role in the pathogenesis of leprosy. However, the benefit of inhibiting angiogenesis in lepromatous leprosy patients has not previously been studied. The purpose of this study was to evaluate angiogenesis in leprosy patients before and after treatment with multidrug therapy (MDT) with and without minocycline.

Development of validated stability-indicating chromatographic method for the determination of fexofenadine hydrochloride and its related impurities in pharmaceutical tablets.

A simple reversed phase high performance liquid chromatographic method with diode array detector (HPLC-DAD) has been developed and subsequently validated for the determination of fexofenadine hydrochloride (FEX) and its related compounds; keto fexofenadine (Impurity A), meta isomer of fexofenadine (Impurity B), methyl ester of fexofenadine (Impurity C) in addition to the methyl ester of ketofexofenadine (Impurity D). The separation was based on the use of a Hypersil BDS C-18 analytical column (250 × 4.6 mm, i.

Multi-objective optimization strategy based on desirability functions used for electrophoratic separation and quantification of rosiglitazone and glimepiride in plasma and formulations.

Multiple response simultaneous optimization employing Derringer's desirability function was used for the development of a capillary electrophoresis method for the simultaneous determination of rosiglitazone (RSG) and glimepiride (GLM) in plasma and formulations. Twenty experiments, taking the two resolutions, the analysis time, and the capillary current as the responses with three important factors--buffer morality, volte and column temperature--were used to design mathematical models. The experimental responses were fitted into a second order polynomial and the six responses were simultaneously optimized to predict the optimum conditions for the effective separation of the studied compounds.

Selective kinetic spectrophotometric method for determination of gatifloxacin based on formation of its N-vinyl chlorobenzoquinone derivative.

A selective and simple kinetic spectrophotometric has been developed, for the first time, for the determination of gatifloxacin (GAT) in its dosage forms. The method was based on the formation of a colored N-vinyl chlorobenzoquinone derivative of GAT by its reaction with 2,3,5,6-tetrachloro-1,4-benzoquinone in presence of acetaldehyde. The formation of the colored product was monitored spectrophotometrically by measuring the absorbances at 655 nm.

Novel selective kinetic spectrophotometric method for determination of norfloxacin in its pharmaceutical formulations.

Novel selective and simple kinetic spectrophotometric method has been developed and validated for the determination of norfloxacin (NOR) in its pharmaceutical formulations. The method was based on the reaction of N-vinylpiprazine formed from the interaction of the mono-substituted piprazinyl group in NOR and acetaldehyde with 2,3,5,6-tetrachloro-1,4-benzoquinone to give colored N-vinylpiprazino-substituted benzoquinone derivative. The formation of the colored product was monitored spectrophotometrically by measuring the absorbance at 625 nm.