Portable solid-state sensor for therapeutic monitoring of an antineoplastic drug; vinblastine in human plasma.

During cancer treatment, doses must be carefully administered and monitored to guarantee efficacy and minimize side-effects. A potentiometric sensor was developed for the direct real-time assay of a widely used antineoplastic drug (vinblastine (VB)) in plasma samples. Membrane cocktails were drop-casted over a glassy-carbon electrode coated with a lipophilic conducting polymer (polyaniline).

Traditional versus advanced chemometric models for the impurity profiling of paracetamol and chlorzoxazone: Application to pure and pharmaceutical dosage forms.

Traditional Partial Least Squares (PLS) and Advanced Artificial Neural Network (ANN) models were applied for the quantitative determination of paracetamol (PAR) and chlorzoxazone (CZX) together with their process-related impurities namely; 4-aminophenol (AP), 4‑chloroacetanilide (AC), 4‑nitrophenol (NP), 4‑chlorophenol (CP) and 2‑amino-4-chlorophenol (ACP). Both models were applied first to full spectrum data then the results were compared to those obtained after wavelength selection using Genetic Algorithm (GA). A 5-level 7-factor experimental design was used giving rise to 25 mixtures containing different proportions of the seven compounds.