Publications by authors named "Maha Mabrook"
Infection caused by K. pneumoniae is associated with severe inflammation due to stimulation of the innate immune components including the complement system, which is the main player of the innate immune response. Excessive complement-mediated inflammation may cause severe lung injury.
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- Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are serious conditions caused by factors like trauma or infection, leading to major inflammation and damage in lung tissues due to neutrophil activity.
- Researchers found that a recombinant chemotaxis inhibitory protein (rCHIPS) from Staphylococcus aureus can effectively reduce the severity of ALI/ARDS in mice by decreasing lung inflammation and permeability after exposure to harmful substances.
- Treatment with rCHIPS leads to reduced levels of inflammatory markers, less neutrophil and leukocyte recruitment, and improved lung health, indicating its potential as a therapeutic option for treating ALI/ARDS.