In sight on olive oil maceration and supercritical CO in extracting rosemary essential oil.

The flavor, nutritional, and medicinal value of rosemary are well known. Hydrodistilled (HD) essential oil was prepared in the present study as a standard. Olive oil maceration (OM) and supercritical carbon dioxide (SC-CO) technology were separately applied to extract the essential oil of rosemary.

Bioactive compounds from : structure identification, antiproliferative, antimigratory, antiangiogenic, and antiadenoviral activities.

During our exploring the anticancer activity of some medicinal plants and their major metabolites, the aerial parts of the Egyptian (flowers and stems) were studied. GC-MS analysis of the organic soluble extracts of the flowers and stems fractions revealed the presence of 43 and 45 compounds, respectively. Individual chromatographic purification of the flowers and stems' extracts afforded three major compounds.

Monascin and monascinol, azaphilonoid pigments from AM1: and targeting of the angiogenic VEGFR2 kinase.

The fungus, is one of the most productive sources of anticancer bioactive compounds namely those of pigment nature. During our investigation of the produced bioactive metabolites by the terrestrial AM1 isolated from Egyptian poultry feather waste, two main azaphilonoid pigments, monascin () and monascinol () were obtained as major products; their structures were identified by 1D (H&C) and 2D (H-H COSY, HMBC) NMR and HRESI-MS spectroscopic data. Biologically, cytotoxic activities of these compounds were broadly studied compared with the fungal extract.

Cardenolides and pentacyclic triterpenes isolated from leaves: their biological activities with molecular docking study.

Pentacyclic triterpenes and cardenolides were isolated from leaves. Their chemical structures were determined based on comprehensive 1D and 2D NMR spectroscopy. Their MIC was determined against 12 microorganisms.

chemotherapeutic and antiangiogenic properties of cardenolides from (Hochst.) Codd.

Acovenoside A (Acov-A) and acobioside A (Acob-A) were isolated from . Their anticancer properties were explored regarding, antiproliferative and antiangiogenic activities. The study included screening phase against six cancer cell lines followed by mechanistic investigation against HepG2 cancer cell line.

Metal-free domino amination-Knoevenagel condensation approach to access new coumarins as potent nanomolar inhibitors of VEGFR-2 and EGFR.

A metal-free, atom-economy and simple work-up domino amination-Knoevenagel condensation approach to construct new coumarin analogous ( and ) was described. Further, new formyl () and nitro () coumarin derivatives were synthesized via C-N coupling reaction of various cyclic secondary amines and 4-chloro-3-(formyl-/nitro)coumarins (), respectively. The confirmed compounds were screened for their anti-proliferative activity against KB-3-1, A549 and PC3 human cancer cell lines using resazurin cellular-based assay.

Antiproliferative and Antiangiogenic Properties of New VEGFR-2-targeting 2-thioxobenzo[]quinazoline Derivatives (In Vitro).

A series of 3-ethyl(methyl)-2-thioxo-2,3-dihydrobenzo[]quinazolines (-) were synthesized, characterized, and evaluated in vitro for their antiangiogenesis VEGFR-2-targeting, antiproliferative, and antiapoptotic activities against breast MCF-7 and liver HepG2 cells. Flow cytometry was used to determine cancer-cell cycle distributions, and apoptosis was detected using annexin-V-FITC (V) and propidium iodide (PI) dyes. Fluorescence microscopy, in combination with Hoechst staining was used to detect DNA fragmentation.

Calamusins J-K: new anti-angiogenic sesquiterpenes from .

Chemical investigation of the organic extract of the marine soft coral from Red Sea, Egypt, afforded two new hydroazulenes; calamusin J () and its hydroperoxide derivative calamusin K () in addition to eight known compounds. Structure of compounds were confirmed by intensive NMR and mass spectrometry studies. The coral extract and the obtained compounds were examined against a set of diverse microorganisms.

Synthesis and biological evaluation of novel 5-chloro--(4-sulfamoylbenzyl) salicylamide derivatives as tubulin polymerization inhibitors.

A novel series of sulfonamide derivatives, coupled with a salicylamide scaffold, was designed and synthesized. The structures of the synthesized compounds were established using H NMR, C NMR and high-resolution mass spectroscopy. The synthesized compounds were tested against five types of human cell lines.

Phylogenetic Analysis and Biological Evaluation of Marine Endophytic Fungi Derived from Red Sea Sponge Hyrtios erectus.

Forty-four endophytic fungal isolates obtained from marine sponge, Hyrtios erectus, were evaluated and screened for their hydrolase activities. Most of the isolates were found to be prolific producers of hydrolytic enzymes. Only 11 isolates exhibited maximum cellular contents of lipids, rhamnolipids, and protein in the fungal isolates under the isolation numbers MERVA5, MERVA22, MERVA25, MERVA29, MERVA32, MERVA34, MERV36, MERVA39, MERVA42, MERVA43, and MERVA44.

Phenolic constituents of Pulicaria undulata (L.) C.A. Mey. sub sp. undulata (Asteraceae): Antioxidant protective effects and chemosystematic significances.

One new naturally isoflavone compound, 5,7,2',3',4' penta hydroxyl isoflavone-4'-O-β-glucopyranoside (1) was isolated from the aqueous methanol extract (AME) of Pulicaria undulata subsp. undulata, together with seven known compounds: kaempferol (2), kaempferol 3-O-β-glucoside (3), quercetin (4), quercetin 3-O-β-glucoside (5), quercetin 3-O-β-galactoside (6), quercetin 3,7-di OCH (7), and caffeic acid (8). Their structures were established through chemical (acid hydrolysis) and spectral analysis (UV, NMR, and ESIM).

Differential effects of c-myc and ABCB1 silencing on reversing drug resistance in HepG2/Dox cells.

Multidrug resistance (MDR) in various kinds of cancers represents a true obstacle which hinders the successes of most of current available chemotherapies. ATP-binding cassette (ABC) trasporter proteins have been shown to contribute to the majority of MDR in various types of malignancies. c-myc has recently been reported to participate, at least partly, in MDR to some types of cancers.

In-vitro evaluation of selected Egyptian traditional herbal medicines for treatment of Alzheimer disease.

Background: Egyptians recognized the healing power of herbs and used them in their medicinal formulations. Nowadays, "Attarin" drug shops and the public use mainly the Unani medicinal system for treatment of their health problems including improvement of memory and old age related diseases. Numerous medicinal plants have been described in old literature of Arabic traditional medicine for treatment of Alzheimer's disease (AD) (or to strengthen memory).

Antiviral screening of forty-two Egyptian medicinal plants.

Aim Of The Study: Egyptian medicinal plants are well known by their diverse uses in traditional folk medicine to cure various ailments including infectious diseases. Forty-two Egyptian medicinal plant species were selected from local market and were subjected to antiviral screening bioassay to investigate and to evaluate their biological activities.

Materials And Methods: Hydro-alcoholic extracts of each species were separately prepared and tested against three viruses: herpes simplex-1 virus (HSV), poliomyelitis-1 virus (POLIO) and vesicular stomatitis virus (VSV).