Pentoxifylline in patients with ulcerative colitis treated with mesalamine by modulation of IL-6/STAT3, ZO-1, and S1P pathways: a randomized controlled double-blinded study.

Background: Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) that lasts a long time and has a variety of causes.

Aim: The primary aim of this study was to evaluate pentoxifylline's (PTX) essential function in patients with UC.

Methods: Fifty-two mild to moderate UC patients who matched the eligibility requirements participated in this clinical study.

Repurposing metformin as adjuvant therapy in patients with ulcerative colitis treated with mesalamine: A randomized controlled double-blinded study.

Background: Ulcerative colitis (UC) is a type of inflammatory bowel disease associated with persistent inflammation. Animal studies proved the efficacy of metformin in UC.

Aim: To investigate the potential role of metformin and its protective pathways in patients with UC.

Inflammatory bowel disease: review and future view.

Inflammatory bowel disease (IBD) is chronic problem that cause an inflammation of the intestines. Significant progress has been made in recent years to the field of IBD epidemiology, pathogenesis and treatment and a number of new insights have been created. Also, there is an increasing interest in the discovery of different new aspects related diagnosis and treatment.

Oxidative stress and inflammatory bowel disease.

Inflammatory Bowel Disease (IBD) is a chronic relapsing and remitting inflammatory condition of the gastrointestinal tract. The exact cause of IBD remains undetermined, the condition appears to be related to a combination of genetic and environmental factors. While many gaps in our knowledge still exist, the last two decades have witnessed an unprecedented progress not only in the etiology ; but mainly in the mechanisms underlying the chronic inflammatory response, immunologic and genetic aspects.

Study of respiratory disorders in endoscopically negative and positive gastroesophageal reflux disease.

Background/aim: The relation between respiratory disorders and reflux symptoms has been debated since the beginning of the last century and the interest in this question has increased during the last few decades. This study aims to investigate the relation between specified respiratory disorders and reflux symptoms and examine the correlations between respiratory disorders and endoscopic findings in patients with gastroesophageal reflux disease.

Patients And Methods: This study included 515 patients evaluated for gastroesophageal reflux disease (GERD) by patient self-report symptom questionnaire; modified four grade Likert scale and endoscopic assessment using endoscopic Los Angeles Classification.

Simplified Early Predictors of Severe Acute Pancreatitis: A Prospective Study.

Background: To propose simple tests for the prediction of severe acute pancreatitis (SAP), which are accurate and could be performed at emergency departments and outpatient clinics.

Methods: A prospective study was performed on 149 patients admitted with acute pancreatitis. Body mass index (BMI), plain chest radiograph, blood biochemical data were obtained at the time of admission; white cell, lymphocyte and platelet counts, hematocrit level, prothrombin time, PaO, creatinine, calcium, blood sugar, total protein, aspartate aminotransferase, total bilirubin, amylase, lipase and C-reaction protein were determined.

Study of Chronic Hepatopathy in Patients With Sickle Cell Disease.

Background: Hepatic lesions in sickle cell disease were studied essentially in autopsy specimens. We investigated chronic hepatopathy in living adults with sickle cell disease and report the clinical, biochemical, and hepatic histological findings in these patients.

Methods: A total of 170 adult patients with sickle cell syndrome were prospectively investigated.

Assessment of thrombophilic abnormalities during the active state of inflammatory bowel disease.

Background/aims: Thromboembolic disease has been recognized as a complication of inflammatory bowel disease (IBD). The relative contributions of inherited or acquired thrombophilia and the inflammatory response to the mechanism of this tendency are unclear. Thrombotic events are more common in active disease although significant numbers also occur spontaneously.

Acute cytomegalovirus infection is a risk factor in refractory and complicated inflammatory bowel disease.

The role of cytomegalovirus (CMV) infection in patients with inflammatory bowel disease (IBD) is controversial. Although CMV has been specifically associated with refractory disease, the strength and nature of this association have been a subject of debate. The aim of this study was to evaluate the prevalence and outcome of acute cytomegalovirus infection in patients with severe refractory and complicated inflammatory bowel disease.

Black esophagus: a case report.

The black esophagus is a rare observation during upper endoscopy. We describe a case of a male with chronic obstructive pulmonary disease, hypertension, diabetes, acute renal failure and in septic state, who developed a black esophagus after hypotensive episodes. The clinical, endoscopic and histopathological characteristics are presented.