Clinical significance of vascular endothelial growth factor (VEGF) in sera of patients with pediatric malignancies.

Background: Angiogenesis is essential for solid tumor growth. It is induced by tumor cells through stimulatory angiogenic peptides, one such peptide is vascular endothelial growth factor (VEGF).

Purpose: The ultimate aim of the work is to investigate the possible role of VEGF as an early biomolecule involved in the progression of pediatric malignant tumors with high metastatic potential.