Publications by authors named "Maha F Al-Subaie"
Background: Malaria continues to be a critical public health concern in India, predominantly driven by complex interplays of ecological, climatic, and socioeconomic factors.
Methods: This study aimed to assess the association between climatic variables (temperature and precipitation) and malaria incidence across India from 2010 to 2019, utilizing data from the Global Historical Weather and Climate Data for climate metrics and the Global Burden of Disease Study for malaria incidence rates. Generalized Linear Mixed Models (GLMMs) with a Poisson distribution were employed to analyze the data, adjusting for socio-economic status, as indexed by the Human Development Index (HDI).
Dengue fever, caused by the dengue virus and transmitted through Aedes mosquitoes, is a growing public health concern, particularly in tropical and subtropical regions. Traditionally associated with febrile and hemorrhagic symptoms, recent research suggests a potential link between dengue and cognitive impairments. This systematic review assessed existing research to understand the association between dengue virus infection and cognitive impairments, including dementia, Alzheimer disease, memory loss, and confusion.
View Article and Find Full Text PDFBackground: Malaria in pregnancy is a critical public health issue that can lead to severe adverse outcomes for both mother and fetus. This systematic review and meta-analysis evaluated the prevalence of adverse birth outcomes in malaria-infected pregnancies and examines their association with the condition.
Method: We searched databases up to January 30, 2024, for observational studies on pregnant women with malaria.
Article Synopsis
- Multisystem Inflammatory Syndrome in Children (MIS-C) linked to COVID-19 can cause serious heart issues, and Anakinra might help by reducing inflammation and improving heart function.
- A systematic review analyzed studies on Anakinra's effects on cardiac outcomes in MIS-C patients, finding significant improvements in heart metrics and inflammation in several studies, although some results were mixed.
- Despite promising findings on Anakinra's potential benefits, the data mainly come from observational studies, highlighting the need for more rigorous randomized controlled trials to confirm its effectiveness and refine treatment strategies.
Article Synopsis
- Cervical cancer in India is largely caused by HPV and has high morbidity and mortality rates, emphasizing the need for understanding regional HPV prevalence for effective public health strategies.
- A systematic review and meta-analysis examined 17 studies with 2,529 cervical cancer cases, finding a pooled HPV prevalence of 85%, but noted substantial regional variations across different parts of India.
- Results indicate the importance of further research due to the complex epidemiology of HPV, as significant differences in prevalence were observed in various geographic zones within the country.
Article Synopsis
- Researchers are exploring drug discovery strategies to fight the human monkeypox virus (MPXV) due to the lack of effective treatments.
- A network-based approach identified 160 proteins involved with MPXV, revealing 39 key proteins for potential drug targets, including 15 existing medications.
- Four specific drugs (Baricitinib, Infliximab, Adalimumab, and Etanercept) and a new molecule (ZINC22060520) show promise for repurposing to treat MPXV infection.
Article Synopsis
- - The study systematically reviews the prevalence of human papillomavirus (HPV) in head and neck cancers (HNCs) in India, finding a pooled HPV infection rate of 33% among 4654 patients across 33 studies.
- - Subgroup analysis shows significant regional differences in prevalence: 47% in eastern India compared to 19.8% in western India, indicating notable heterogeneity in the data.
- - The researchers emphasize the importance of integrating HPV vaccination and screening in public health strategies, and recommend further research to understand regional variations and factors influencing HPV-associated HNC treatment responses.
Purpose: In the wake of the COVID-19 pandemic, vaccines have been pivotal in curbing disease spread and severity. However, concerns over post-vaccination adverse events, including uveitis, an inflammatory ocular condition, have been noted. This systematic review and meta-analysis aimed to evaluate the incidence and association of uveitis following COVID-19 vaccination.
View Article and Find Full Text PDFBackground: The unprecedented emergence of the COVID-19 pandemic necessitated the development and global distribution of vaccines, making the understanding of global vaccine acceptance and hesitancy crucial to overcoming barriers to vaccination and achieving widespread immunization.
Objective: This umbrella review synthesizes findings from systematic reviews and meta-analyses to provide insights into global perceptions on COVID-19 vaccine acceptance and hesitancy across diverse populations and regions.
Methods: We conducted a literature search across major databases to identify systematic reviews and meta-analysis that reported COVID-19 vaccine acceptance and hesitancy.
Wild birds could be a reservoir of medically relevant microorganisms, particularly multidrug-resistant Enterococcus spp. Resistant bacteria's epidemiology and transmission between animals and humans has grown, and their zoonotic potential cannot be ignored. This is the first study to evaluate the status of vancomycin resistant enterococci (VRE) in various wild bird species using meta-analysis and a systematic review.
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- Marburg virus infections have a high fatality rate of 23% to 90%, prompting the need for effective therapeutic strategies targeting its VP24 protein.
- A molecular dynamics simulation study screened 484 anti-dengue compounds, identifying five potential inhibitors, with two compounds demonstrating strong stability and binding energies to the VP24 protein across various temperatures.
- The study found that one compound showed a maximum dissociation force indicating robust binding, making it a promising candidate for further in-vitro testing to validate its efficacy in inhibiting VP24 function.
Recent monkeypox virus (MPXV) infections show the risk of MPXV transmission that persists today and the significance of surveillance and quick response methods to stop the virus's spread. Currently, the monkeypox virus infection is not specifically treated. In this study, QSAR models were designed using known inhibitors of cysteine proteinase from the vaccinia virus, where the Random Forest model and Ridge model had showed the best correlation between predicted and observed EC.
View Article and Find Full Text PDFBackground: Cardiovascular disease (CVD) and dengue are both significant global health concerns, and their intersection presents a growing clinical challenge. Emerging evidence suggests that individuals with pre-existing CVD may face an elevated risk of severe dengue outcomes. The present study aims to perform a systematic review to assess the relationship between CVD and the severity of dengue.
View Article and Find Full Text PDFBackground And Aim: Hepatocellular carcinoma (HCC) is a significant complication of hepatitis B and still poses a global public health concern. This systematic review and meta-analysis provide adequate details on the prevalence of HCC in the HBV population within Southeast Asian countries.
Method: Following the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) criteria, a thorough search for literature discussing the prevalence of HCC in the HBV population within southeast Asia was performed.
SARS-CoV-2, responsible for COVID-19, shares 79% and 50% of its identity with SARS-CoV-1 and MERS-CoV, respectively. It uses the same main cell attachment and entry receptor as SARS-CoV-1, which is the ACE-2 receptor. However, key residues in the receptor-binding domain of its S-protein seem to give it a stronger affinity for the receptor and a better ability to hide from the host immune system.
View Article and Find Full Text PDFDespite the effectiveness of current vaccines in reducing the spread and severity of SARS-CoV-2 infections, many people, including migrants, refugees, and foreign workers, are hesitant to be vaccinated. This systematic review and meta-analysis (SRMA) was conducted to determine the pooled prevalence estimate of the acceptance and hesitancy rates of the COVID-19 vaccine among these populations. A comprehensive search of the peer-reviewed literature indexed in PubMed, Scopus, Science Direct, and Web of Science databases was conducted.
View Article and Find Full Text PDFBackground: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged from China in December 2019 and has presented as a substantial and serious threat to global health. We aimed to describe the clinical, epidemiological, and laboratory findings of patients in Saudi Arabia infected with SARS-CoV-2 to direct us in helping prevent and treat coronavirus disease 2019 (COVID-19) across Saudi Arabia and around the world.
Materials And Methods: Clinical, epidemiological, laboratory, and radiological characteristics, treatment, and outcomes of pediatric and adult patients in five hospitals in Riyadh, Saudi Arabia, were surveyed in this study.
Introduction: The ongoing pandemic of the coronavirus disease 2019 (COVID-19) is a global health concern. It has affected more than 5 million patients worldwide and resulted in an alarming number of deaths globally. While clinical characteristics have been reported elsewhere, data from our region is scarce.
View Article and Find Full Text PDFObjectives: To assess current practices of different healthcare providers for treating extensively drug-resistant (XDR) Acinetobacter baumannii (AB) infections in tertiary-care centers in Saudi Arabia.
Methods: This cross-sectional study was performed in tertiary-care centers of Saudi Arabia between March and June 2014. A questionnaire consisting of 3 parts (respondent characteristics; case scenarios on ventilator-associated pneumonia [VAP] and tracheobronchitis [VAT], and antibiotic choices in each scenario) was developed and sent electronically to participants in 34 centers across Saudi Arabia.