Conflicting data exist regarding the effectiveness of oral iron therapy in treating iron deficiency (ID) and iron deficiency anemia (IDA), particularly in relation to DNA damage and oxidative stress.
The study assessed DNA damage, oxidative stress, and antioxidant markers in children with ID and IDA before and after 8 weeks of low-dose oral iron therapy, using various biochemical assays.
Results showed that while DNA damage was initially higher in ID and IDA groups compared to healthy controls, low-dose iron therapy improved hematological parameters and antioxidant status, reducing DNA damage significantly in both ID and IDA children.