Publications by authors named "Maha Alshiekheid"

This study presents the ex situ development and characterization of bacterial cellulose (BC) membranes loaded with bioactive Sage and Neem extracts for enhanced antimicrobial applications. Utilizing discarded fruit waste as a cost-effective carbon source, BC production was optimized, yielding membranes with improved properties. Neem and Sage extracts, obtained via Soxhlet extraction, exhibited significant antibacterial activity against Escherichia coli and Staphylococcus aureus, with minimum inhibitory concentrations of 3.

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Article Synopsis
  • - A newly identified bacterial strain, Stenotrophomonas geniculata MK2, effectively controls gray mold on strawberries, demonstrating 85% inhibition of the pathogen Botrytis cinerea in lab tests and 88% efficacy on detached fruits.
  • - Whole genome sequencing revealed MK2 has a circular chromosome with a size of 736,465 bp, featuring a high coding ratio and numerous genes primarily involved in metabolic processes and general functions.
  • - The strain produces various secondary metabolites linked to biocontrol properties, showing potential for use as a natural agent against postharvest diseases in strawberries.
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Background: Malaria continues to be a critical public health concern in India, predominantly driven by complex interplays of ecological, climatic, and socioeconomic factors.

Methods: This study aimed to assess the association between climatic variables (temperature and precipitation) and malaria incidence across India from 2010 to 2019, utilizing data from the Global Historical Weather and Climate Data for climate metrics and the Global Burden of Disease Study for malaria incidence rates. Generalized Linear Mixed Models (GLMMs) with a Poisson distribution were employed to analyze the data, adjusting for socio-economic status, as indexed by the Human Development Index (HDI).

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Dengue virus (DENV) remains one of the most common arboviral infections threatening humans. This study was conducted to systematically review the available literature and provide an updated overview of the overall prevalence of DENV infection in Saudi Arabia. The prevalence data was pooled from 21,891 participants recruited in 17 studies.

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Non-coding RNAs (ncRNAs) contain circular RNAs (circRNAs), long non-coding RNAs (lncRNAs), and micro-ribonucleic acids (miRNAs). These RNAs receive good functionality in modulation of gene expressions & cellular roles. Recent research is shedding light on their pivotal roles in the pathophysiology of inflammatory meningitis, such as viral, fungal, or bacterial infections.

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In this study, the phytochemical profile and silver nanoparticle (AgNPs)-synthesizing ability of Pittosporum undulatum methanol extract were investigated. Furthermore, biological applications of the AgNPs, such as antibacterial effect (against Klebsiella pneumoniae, Staphylococcus aureus, Bacillus subtilis, and Escherichia coli), mosquito larvicidal effect (against Anopheles stephensi, Culex quinquefasciatus, and Aedes aegypti), and cytotoxicity (against fibroblast cell line L929) were evaluated using in vitro experiments. The phytochemical analysis revealed that the methanol extract contained cardiac glycosides, terpenoids, saponins, alkaloids, flavonoids, glycosides, coumarins, phenolics, and tannins.

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The study was conducted to determine the chemical and structural properties of polysaccharides extracted from the marine macroalgae Nemalion cari-cariense. Furthermore, evaluate the anticancer and free radical scavenging activity of purified N. cari-cariense polysaccharide.

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is a pathogenic bacterial species belonging to the family and it is mainly considered the etiological agent of chronic obstructive pulmonary diseases associated with cystic fibrosis, due to being intrinsic antibiotic resistant making it difficult to treat pulmonary infections. Hence increased rate of antibiotic-resistant bacterial species vaccine development is the priority to tackle this problem. In research work, we designed a multi-epitope-based vaccine construct against using reverse vaccinology immunoinformatics and biophysical approaches.

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Developing new antibiotics is a critical area of research that grows as a result of the increasing problem of antibiotic resistance. Scientists search for new antibiotics by screening natural sources such as soil, plants, and marine environments. One of the iconic plants in the marine environment is the mangrove, which is a source of honeybee propolis.

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: Periodontitis is a chronic multifactorial inflammatory infectious disease marked by continuous degradation of teeth and surrounding parts. One of the most important periodontal pathogens is , and with its interpain A proteinase, it leads to an increase in lethal infection. : The current study was designed to create a multi-epitope vaccine using an immunoinformatics method that targets the interpain A of .

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Antimicrobial resistance (AMR) is a leading cause of treatment failure for many infectious diseases worldwide. Improper overdosing and the misuse of antibiotics contributes significantly to the emergence of drug-resistant bacteria. The co-contamination of heavy metals and antibiotic compounds existing in the environment might also be involved in the spread of AMR.

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Article Synopsis
  • Improper use of antimicrobials has led to a rise in antimicrobial resistance (AMR), particularly the concerning trend of Carbapenem-resistant Enterobacteriaceae (CRE), posing treatment challenges for infected individuals.
  • Bacterial plasmids facilitate the spread of resistance genes among bacteria, and the incidence of CRE continues to rise despite efforts to combat it, necessitating improved identification methods that often require integrated approaches.
  • The review discusses the mechanisms behind Carbapenem resistance, the epidemiology and treatment options for CRE, and emphasizes the need for antibiotic stewardship programs to manage antibiotic use and curb the spread of resistance globally.
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The epidemiological and clinical aspects of coronavirus disease-2019 (COVID-19) have been subjected to several investigations, but little is known about symptomatic patients with negative SARS-CoV-2 PCR results. The current study investigated patients who presented to the hospital with respiratory symptoms (but negative SARS-CoV-2 RT-PCR results) to determine the prevalence of bacterial pathogens among these patients. A total of 1246 different samples were collected and 453 species of bacterial pathogens were identified by culture.

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Background and Objectives: Citrobacter freundii (C. freundii) is an emerging and opportunistic Gram-negative bacteria of the human gastrointestinal tract associated with nosocomial and severe respiratory tract infections. It has also been associated with pneumonia, bloodstream, and urinary tract infections.

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(1) Background: SARS-CoV-2 Omicron BA.1 is the most common variation found in most countries and is responsible for 99% of cases in the United States. To overcome this challenge, there is an urgent need to discover effective inhibitors to prevent the emerging BA.

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Leveraging machine learning has been shown to improve the accuracy of structure-based virtual screening. Furthermore, a tremendous amount of empirical data is publicly available, which further enhances the performance of the machine learning approach. In this proof-of-concept study, the 3CL enzyme of SARS-CoV-2 was used.

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Vaccines are vital for prevention and control of mycoplasma diseases. The exploration of a vaccine candidate for the development of a vaccine is imperative. The present study envisages the evaluation of immune and oxidative response against an adjuvanted, sonicated antigen of Mycoplasma capricolum subsp.

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is mainly responsible for sepsis, urethritis, and respiratory tract infections. These bacteria may affect the transcription of the host and particularly their immune system by producing changes in their epigenetics. In the present study, four proteins of were used to predict the epitopes for the construction of an mRNA vaccine against infections.

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In this report, the green fabrication of copper oxide nanoparticles (CuNPs) using Turnera subulata leaf extract and assessed for the antibacterial and photocatalytic activities. The synthesis of CuNPs was performed using the leaves of T. subulata (TS-CuNPs) and characterized using UV-visible spectrophotometry, Fourier transforms infrared spectroscopy (FT-IR), Scanning electron microscopy (SEM), and Energy-dispersive X-ray spectroscopy (EDX).

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The present study focused on microwave assisted synthesis of zirconium nanoparticles (ZrONPs) using leaf extract of Phyllanthus niruri as ecofriendly approach and assessed its antimicrobial and bioremediation efficiency. Visual color transition from yellow to brown indicates the formation of ZrONPs which was further substantiated by UV-Visible absorption peak at 300 nm. Dynamic Light Scattering (DLS) analysis revealed that the average particle size of ZrONPs as 121.

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In currently, biosynthesis of copper oxide nanoparticles (CuO NPs) are most widely used numerous in biological applications such as biosensor, energy, medicine, agriculture, environmental and industrial wastewater treatment. The hierarchical CuO NPs was synthesized via green chemistry method by using of Abutilon indicum (A. indicum) leaf extract, its nontoxic, facile and low-cost approaches.

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The phytoremediation potency of Gossypium hirsutum was explored in this research under the influence of pre-identified metal tolerant Streptomyces tritici D5 in Cr enriched sludge soil using various treatment sets (I to V) in a greenhouse setting. Interestingly, the G. hirsutum remarkable remediate the Cr metal from the Cr enriched sludge soil under diluted (50:50) condition in 90 days of greenhouse experiment.

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This study was carried out in order to find an environmentally friendly solution to recover the abandoned Cr-enriched sludge soil, which causes a variety of environmental issues. Hence, in this research the influence of pre-identified Brevibacillus borstelensis UTM105 and Brevibacillus borstelensis AK2 coated Jatropha curcas seed in phytoremediation process with various treatment groups (group A to F) under greenhouse condition. Furthermore, their influence on growth, biomolecules (total proteins and total chlorophyll) content, and antioxidant activity of J.

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The copper nanoparticles (CuNPs) synthesizing potential of Cynodon dactylon aqueous leaf extract and their antibacterial as well as dye degradation potentials were investigated. The synthesized CuNPs was initially characterized by gradual colour change from dark brown to blue in colour and then found absorbance peak at 469 nm. Furthermore, the SEM and DLS analyses showed that biosynthesized CuNPs were spherical in shaped and size ranging from 120 to 129 nm.

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