4-nitroquinoline 1-oxide-induced oral epithelial lesions exhibit time- and stage-dependent changes in the tumor immune microenvironment.

Oral tongue squamous cell carcinoma (OTSCC) is the most common cancer of the oral cavity and is associated with high morbidity due to local invasion and lymph node metastasis. Tumor infiltrating lymphocytes (TILs) are associated with good prognosis in oral cancer patients and dictate response to treatment. Ectopic sites for immune activation in tumors, known as tertiary lymphoid structures (TLS), and tumor-associated high-endothelial venules (TA-HEVs), which are specialized lymphocyte recruiting vessels, are associated with a favorable prognosis in OSCC.

Doctored photographs create false memories of spectacular childhood events. a replication of Wade et al. (2002) with a Scandinavian twist.

Can exposure to a doctored photograph of a plausible yet fictitious childhood event create false memories in adults? Twenty years ago, (Wade, K. A., Garry, M.

Amphipathic barbiturates as marine product mimics with cytolytic and immunogenic effects on head and neck squamous cell carcinoma cell lines.

The incidence of head and neck squamous cell carcinoma (HNSCC) is increasing and the conventional treatments for this form of cancer can be tough. Despite the success of existing immunotherapies in some HNSCC patients, many do not respond to this type of treatment. Thus, the development of novel anti-cancer therapies should be prioritized.

The marine natural product mimic MPM-1 is cytolytic and induces DAMP release from human cancer cell lines.

Bioprospecting contributes to the discovery of new molecules with anticancer properties. Compounds with cytolytic activity and the ability to induce immunogenic cell death can be administered as intratumoral injections with the aim to activate anti-tumor immune responses by causing the release of tumor antigens as well as damage-associated molecular patterns (DAMPs) from dying cancer cells. In the present study, we report the cytolytic and DAMP-releasing effects of a new natural product mimic termed MPM-1 that was inspired by the marine Eusynstyelamides.

The Science of Lie Detection by Verbal Cues: What Are the Prospects for Its Practical Applicability?

There is agreement among researchers that no simple verbal cues to deception detectable by humans have been demonstrated. This paper examines the evidence for the most prominent current methods, critically considers the prevailing research strategy, proposes a taxonomy of lie detection methods and concludes that two common types of approach are unlikely to succeed. An approach to lie detection is advocated that derives both from psychological science and common sense: When an interviewee produces a statement that contradicts either a previous statement by the same person or other information the authorities have, it will in many cases be obvious to interviewer and interviewee that at least one of the statements is a lie and at the very least the credibility of the witness is reduced.

Pericyte, but not astrocyte, hypoxia inducible factor-1 (HIF-1) drives hypoxia-induced vascular permeability in vivo.

Background: Ways to prevent disease-induced vascular modifications that accelerate brain damage remain largely elusive. Improved understanding of perivascular cell signalling could provide unparalleled insight as these cells impact vascular stability and functionality of the neurovascular unit as a whole. Identifying key drivers of astrocyte and pericyte responses that modify cell-cell interactions and crosstalk during injury is key.

Validation of Selected Head and Neck Cancer Prognostic Markers from the Pathology Atlas in an Oral Tongue Cancer Cohort.

The Pathology Atlas is an open-access database that reports the prognostic value of protein-coding transcripts in 17 cancers, including head and neck cancer. However, cancers of the various head and neck anatomical sites are specific biological entities. Thus, the aim of the present study was to validate promising prognostic markers for head and neck cancer reported in the Pathology Atlas in oral tongue squamous cell carcinoma (OTSCC).

Nephronectin as a Matrix Effector in Cancer.

The extracellular matrix protein nephronectin plays an important regulatory role during embryonic development, controlling renal organogenesis through integrin α8β1 association. Nephronectin has three main domains: five N-terminal epidermal growth factor-like domains, a linker region harbouring two integrin-binding motifs (RGD and LFEIFEIER), and a C-terminal MAM domain. In this review, we look into the domain-related functions of nephronectin, and tissue distribution and expression.

Norwegian judges' knowledge of factors affecting eyewitness testimony: a 12-year follow-up.

Eyewitness evidence often plays a critical role in decisions made in the criminal justice system. To evaluate eyewitness testimony accurately, judges must be aware of factors that can contaminate this type of evidence. In 2008, a survey of judges in Norway revealed a lack of awareness of several factors that affect eyewitness testimony.

Nephronectin promotes breast cancer brain metastatic colonization via its integrin-binding domains.

This study demonstrates a role for the extracellular matrix protein nephronectin (NPNT) in promoting experimental breast cancer brain metastasis, possibly through enhanced binding to- and migration through brain endothelial cells. With the introduction of more targeted breast cancer treatments, a prolonged survival has resulted during the last decade. Consequently, an increased number of patients develop metastasis in the brain, a challenging organ to treat.

A Novel Truncated Form of Nephronectin Is Present in Small Extracellular Vesicles Isolated from 66cl4 Cells.

Extracellular vesicles are emerging as biomarkers in breast cancer. Our recent report suggested that an intracellular granular staining pattern of the extracellular matrix protein nephronectin (NPNT) in breast tumor sections correlated with a poor prognosis. Furthermore, the results showed that NPNT is localized in extracellular vesicles derived from mouse breast cancer cells.

A unified framework for land cover monitoring based on a discrete global sampling grid (GSG).

Environmental monitoring and assessment of the extent and change of land uses and their renewable natural resources over time is a key element in many international processes and one crucial basis for sustainable management. Remote sensing plays an increasingly important role in these monitoring systems, especially if the interest is in large areas. Integration of remote sensing requires comprehensive and careful preprocessing and a high level of expertise which is not always at hand in all applications.

Nephronectin mediates p38 MAPK-induced cell viability via its integrin-binding enhancer motif.

Nephronectin (NPNT) is an extracellular matrix (ECM) protein involved in kidney development. We recently reported intracellular NPNT as a potential prognostic marker in breast cancer and that NPNT promotes metastasis in an integrin-dependent manner. Here, we used reverse-phase protein array (RPPA) to analyze NPNT-triggered intracellular signaling in the 66cl4 mouse breast cancer cell line.

Pillars or Pancakes? Self-Cleaning Surfaces without Coating.

Surfaces that stay clean when immersed in water are important for an enormous range of applications from ships and buildings to marine, medical, and other equipment. Up until now the main strategy for designing self-cleaning surfaces has been to combine hydrophilic/hydrophobic coatings with a high aspect ratio structuring (typically micron scale pillars) to trap a (semi)static water/air layer for drag and adhesion reduction. However, such coating and structuring can distort optical properties and get damaged in harsh environments, and contamination, i.

Nephronectin is Correlated with Poor Prognosis in Breast Cancer and Promotes Metastasis via its Integrin-Binding Motifs.

Most cancer patients with solid tumors who succumb to their illness die of metastatic disease. While early detection and improved treatment have led to reduced mortality, even for those with metastatic cancer, some patients still respond poorly to treatment. Understanding the mechanisms of metastasis is important to improve prognostication, to stratify patients for treatment, and to identify new targets for therapy.

Cleavage of the urokinase receptor (uPAR) on oral cancer cells: regulation by transforming growth factor - β1 (TGF-β1) and potential effects on migration and invasion.

Background: Urokinase plasminogen activator (uPA) receptor (uPAR) is up-regulated at the invasive tumour front of human oral squamous cell carcinoma (OSCC), indicating a role for uPAR in tumour progression. We previously observed elevated expression of uPAR at the tumour-stroma interface in a mouse model for OSCC, which was associated with increased proteolytic activity. The tumour microenvironment regulated uPAR expression, as well as its glycosylation and cleavage.

The Emotional Child Witness Effect Survives Presentation Mode.

The emotional witness effect - the phenomenon whereby people are affected by the emotional manner in which a witness presents testimony - constitutes a possible source of wrongful decisions in legal contexts. One stereotypical view of abused children is that they should be sad when talking about their experiences of maltreatment, whereas children may in fact express a variety of emotional expressions when talking about abusive events. This raises the question as to whether there is an optimal mode in which to present child victim testimony that could reduce the possible influence of displayed emotions.

Maltreated and non-maltreated children's true and false memories of neutral and emotional word lists in the Deese/Roediger-McDermott task.

Maltreated (n=26) and non-maltreated (n=31) 7- to 12-year-old children were tested on the Deese/Roediger-McDermott (DRM) false memory task using emotional and neutral word lists. True recall was significantly better for non-maltreated than maltreated children regardless of list valence. The proportion of false recall for neutral lists was comparable regardless of maltreatment status.

Model errors in tree biomass estimates computed with an approximation to a missing covariance matrix.

Background: Biomass and carbon estimation has become a priority in national and regional forest inventories. Biomass of individual trees is estimated using biomass equations. A covariance matrix for the parameters in a biomass equation is needed for the computation of an estimate of the model error in a tree level estimate of biomass.

Plectin as a prognostic marker in non-metastatic oral squamous cell carcinoma.

Background: Oral squamous cell carcinoma (OSCC) is associated with a poor 5-year survival rate. In general, patients diagnosed with small tumors have a fairly good prognosis, but some small tumors have an aggressive behavior leading to early death. There are at present no reliable prognostic biomarkers for oral cancers.

Short-term retention of visual information: Evidence in support of feature-based attention as an underlying mechanism.

Retention of features in visual short-term memory (VSTM) involves maintenance of sensory traces in early visual cortex. However, the mechanism through which this is accomplished is not known. Here, we formulate specific hypotheses derived from studies on feature-based attention to test the prediction that visual cortex is recruited by attentional mechanisms during VSTM of low-level features.

Simulating newborn face perception.

A frequently asked question concerns what a newborn infant can actually see. The contrast sensitivity function of newborn infants is well known, but its implications for the ability of newborns to perceive faces of adults remain unclear. We filtered gray scale animations of facial expressions in terms of both spatial frequency and contrast to correspond to the properties of newborn infants' acuity and showed them to adult participants.

An examination of the causes and solutions to eyewitness error.

Eyewitness error is one of the leading causes of wrongful convictions. In fact, the American Psychological Association estimates that one in three eyewitnesses make an erroneous identification. In this review, we look briefly at some of the causes of eyewitness error.