Publications by authors named "Magnus Osnes"
Article Synopsis
- Streptococcus pneumoniae is a significant global health threat, but pneumococcal conjugate vaccines (PCVs) have notably decreased cases of targeted serotypes.
- Research conducted over 41 years in Norway utilized whole-genome sequencing to analyze historical and contemporary isolates of S. pneumoniae, revealing shifts in serotype populations.
- Findings indicate that while PCVs have decreased invasive disease, they also led to some serotype switching to non-vaccine types, indicating a dynamic evolutionary response in the bacterial population.
Article Synopsis
- - The COVID-19 pandemic prompted rapid development of genomic surveillance methods to analyze the evolution of SARS-CoV-2 in a population without prior immunity.
- - Researchers in Norway used genetic and phylogenetic techniques to track how the virus spread, finding that most cases were related to imported strains and involved cycles of introduction and suppression of new variants.
- - The emergence of the B.1.1.7 variant marked a shift, as it was able to establish itself in the population despite strict border controls, indicating a change in transmission dynamics.
The evolution and emergence of drug-resistant tuberculosis (TB) has been studied extensively in some contexts, but the ecological drivers of these two processes remain poorly understood. This study sought to describe the joint evolutionary and epidemiological histories of a novel multidrug-resistant strain recently identified in the capital city of the Republic of Moldova (MDR Ural/4.2), where genomic surveillance of drug-resistant has been limited thus far.
View Article and Find Full Text PDFThe Neisseria gonorrhoeae multilocus sequence type (ST) 1901 is among the lineages most commonly associated with treatment failure. Here, we analyze a global collection of ST-1901 genomes to shed light on the emergence and spread of alleles associated with reduced susceptibility to extended-spectrum cephalosporins (ESCs). The genetic diversity of ST-1901 falls into a minor and a major clade, both of which were inferred to have originated in East Asia.
View Article and Find Full Text PDFmultilocus sequence type (ST)-7827 emerged in a dramatic fashion in Norway in the period 2016-2018. Here, we aim to shed light on the provenance and expansion of this ST. ST-7827 was found to be polyphyletic, but the majority of members belonged to a monophyletic clade we termed PopPUNK cluster 7827 (PC-7827).
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