Publications by authors named "Magnus Jansson"
Visualization of SV2A conformations in situ by the use of Protein Tomography.
Biochem Biophys Res Commun
October 2008
Article Synopsis
- The study investigates the structural characteristics of the synaptic vesicle protein 2A (SV2A), which is important for the anti-epileptic drug levetiracetam (LEV), using Protein Tomography on mouse brain tissue.
- Two main shapes of SV2A were identified: a compact funnel with a pore-like opening and a V-shaped structure with a cleft, indicating the protein's high flexibility and potential valve-like function.
- The findings suggest that LEV binding does not significantly change the SV2A structure, and the research provides new structural insights that support its function as a transporter, similar to other known transporter proteins.
The epidermal growth factor receptor (EGFR) activates cellular pathways controlling cell proliferation, differentiation, migration, and survival. It thus represents a valid therapeutic target for treating solid cancers. Here, we used an electron microscopy-based technique (Protein Tomography) to study the structural rearrangement accompanying activation and inhibition of native, individual, EGFR molecules.
View Article and Find Full Text PDFESR and theoretical studies of trimer radical cations of coronene.
Spectrochim Acta A Mol Biomol Spectrosc
January 2006
Article Synopsis
- - Highly resolved Electron Spin Resonance (ESR) spectra were obtained for different radical cations (monomer, dimer, and trimer) of coronene in a specific solvent, exhibiting unique isotropic hyperfine splitting constants that help identify the chemical species involved.
- - The observed hyperfine splitting constants for the dimer radical cation matched previously reported values, while the trimer’s constants exhibited notable differences from earlier studies, suggesting a need for reevaluation of existing data.
- - Computational modeling indicated that the trimer cation likely adopts a staggered sandwich structure, with the unpaired electron primarily localized in the central ring, while another less stable structure was also identified, highlighting complexities in the electron distribution of the tr