Outstanding Response to Sorafenib in a Patient with Metastatic Gastrointestinal Stromal Tumour.

Gastrointestinal stromal tumour (GIST) is the most common sarcoma and can be seen in any part of the gastrointestinal tract. The effect of tyrosine kinase inhibitors varies with mutation status in receptor tyrosine kinase KIT and in platelet-derived growth factor receptor A (). This case presents a 61-year-old man, diagnosed with an 11-cm GIST located at the stomach with a high risk of recurrence.

Surgical exploration without resection in pancreatic and periampullary tumors: Report from a national database.

Background And Objective: Pancreatic and periampullary cancers are sometimes found to have a too advanced disease during surgery to allow resection. The aim was to describe characteristics, treatment, outcome, and time trends for patients that were planned for pancreatic surgery but found unresectable during surgery.

Methods: Data from the Swedish National Pancreatic and Periampullary Cancer Registry were used.

Early postoperative fluid retention is a strong predictor for complications after pancreatoduodenectomy.

Background: Perioperative fluid overload has been reported to increase complications after a variety of operative procedures. This study was conducted to investigate the incidence of fluid retention after pancreatic resection and its association with postoperative complications.

Methods: Data from 1174 patients undergoing pancreatoduodenectomy between 2010 and 2016 were collected from the Swedish National Pancreatic and Periampullary Cancer Registry.

Intraoperative liver steatosis characterization using diffuse reflectance spectroscopy.

Background: Liver steatosis is associated with poor outcome after liver transplantation and liver resection. There is a need for an accurate and reliable intraoperative tool to identify and quantify steatosis. This study aimed to investigate whether surface diffuse reflectance spectroscopy (DRS) measurements could detect liver steatosis on humans during liver surgery.

Significance of poor performance status after resection of colorectal liver metastases.

Background: Performance status (PS) is known as one of the strongest prognostic factors for survival in metastatic colorectal cancer patients. The aim of the present study was to analyze factors associated with poor PS assessed after resection for colorectal liver metastases and the impact on survival.

Methods: All patients undergoing curative resection for colorectal liver metastases between 2010 and 2015 in a single center were reviewed retrospectively.

The role of irreversible electroporation (IRE) for locally advanced pancreatic cancer: a systematic review of safety and efficacy.

Objectives: Irreversible electroporation (IRE) is a new modality for tumor ablation. Electrodes are placed around the tumor, and a pulsed, direct current with a field strength of 2000 V/cm is delivered. The direct current drives cells into apoptosis and cell death without causing significant heating of the tissues, which spares the extracellular matrix and proteins.

Endovascular Removal of the Viatorr Stent-Grafts. Report of Two Cases.

Background: The dysfunction of misplaced or dislodged endovascular endoprostheses, may be a serious complication, and endovascular removal may be attempted in some cases.

Case Report: A Viatorr(®) stent-graft (Gore, Flagstaff, AR, USA) is an endoprosthesis designed and commonly used for creation of a transjugular intrahepatic portosystemic shunt (TIPS). Two Viatorrs were accidentally dislodged during TIPS procedure.

Fast-track program for liver resection--factors prolonging length of stay.

Background/aims: Fast-track programs involving multi-modal measures to enhance recovery after surgery, reduce morbidity and decrease hospital length of stay (LOS) are used for different major surgical procedures. For liver resections, factors influencing LOS within a fast-track program have been studied only to a limited extent, which was the aim of the present study.

Methodology: The present study comprises the first 64 patients included in a fast-track program for liver resections introduced in March 2012.

Clinical outcome of percutaneous RF-ablation of non-operable patients with liver metastasis from breast cancer.

Purpose: Despite improved anti-neoplastic treatment the prognosis for patients with liver metastases from metastatic breast cancer remains poor.

Materials And Methods: Thirty-two consecutive patients with metastatic breast cancer treated with radiofrequency ablation (RFA) at the Department of Oncology, Herlev Hospital, University of Copenhagen, from 1996 to 2010.

Results: Time to intrahepatic progression was median 11 months (range 1.

Safety and preliminary efficacy of ultrasound-guided percutaneous irreversible electroporation for treatment of localized pancreatic cancer.

Background: Irreversible electroporation (IRE) is a local tumor treatment. Thin needles are placed percutaneously around the tumor under ultrasound guidance. Short pulses of direct current sent through the tissue irreversibly increase cell membrane permeability leading to cell death.

Multimodal management of colorectal liver metastases and the effect on regeneration and outcome after liver resection.

Management of colorectal liver metastases (CRLM) has dramatically changed during the last decade and has now become more multimodal and aggressive, including the use of downstaging chemotherapy, portal vein embolization to increase the function of the liver remnant or both in combination. Radiofrequency ablation is also an option in CRLM, potentially combined with surgical resection. Results are quite convincing concerning the safety of liver resection also when performed following neoadjuvant chemotherapy.

[Surgical treatment of pancreatic cancer].

Surgery remains the only hope for cure in pancreatic cancer. The most common procedures are reviewed. Postoperative morbidity and mortality below 30% and 5%, respectively, are the standard.

[Abdominal fistula 7 years after laparoscopic cholecystectomy].

A 64-year old female presented with fistulas on the abdomen 7 years after laparoscopic cholecystectomy. During fistula excision, several gallstones were found. Scrutiny of the medical records revealed that spillage of gallstones had occurred during the cholecystectomy.

[Future perspectives in liver surgery].

Resection of colorectal liver metastases will increase due to increased life expectancy and widened indications. Complex combinations of chemotherapy, surgery, and local ablation are used in advanced disease. Advances in laparoscopic and telerobotic liver resection are expected.

[Combined surgical and oncological management of colorectal liver metastases].

Isolated colorectal liver metastases should be referred for multispecialist management at a liver centre. Long-time survival is possible after resection and adjuvant therapy. If unresectable, newer chemotherapy with oxaliplatin, irinitecan, bevacizumab and cetuximab may result in a median survival > 20 months.

[Retroperitoneal sarcomas - size not decisive].

A 70 year-old female presented with a 40 x 40 cm unresectable liposarcoma which showed progression during chemotherapy. After renewed evaluation, a radical resection was done. The second case concerns a 64 year-old male with a 19 x 15 cm liposarcoma in the upper abdomen.

Curative resection for left-sided pancreatic malignancy.

Background: Surgical technique in pancreatic cancer has seen significant developments, but much of the knowledge refers to pancreatic head carcinoma. Reports on the management of tumours of the body and tail have been less frequent. Current knowledge teaches that adenocarcinomas of the body and tail of the pancreas have a worse prognosis.

Successful resection of an advanced duodenal gastrointestinal stromal tumor after down-staging with imatinib: report of a case.

The diagnosis of gastrointestinal stromal tumor (GIST) relies on a combination of the following criteria: anatomic location, typical histopathology, and the presence of CD 117-antigen (the tyrosine kinase receptor, c-kit) or CD 34-antigen. Imatinib mesylate, a specific tyrosine kinase inhibitor, is highly efficient against locally advanced or metastatic GIST. We report a case of unresectable duodenal GIST, which we were able to resect with curative intent after down-staging treatment with a dosage of imatinib 400 mg daily for 8 months.

[Retroperitoneal sarcoma: a multispecialist effort].

A 61-year-old woman presented with a 16 cm retroperitoneal sarcoma, which demanded a multispecialist effort. There was adherence to the left ureter, the iliac vessels, the mesosigmoideum and the small intestine. After angiographic embolization, the tumor, sigmoid colon and left ureter were excised.

Current state of adjuvant therapy in resected pancreatic adenocarcinoma.

Pancreatic carcinoma cannot generally be cured by surgery alone. This review summarizes the development of adjuvant therapy over the past two decades. Four randomized controlled trials compare long-term survival of different treatments.

Recurrent acute pancreatitis due to eosinophilic gastroenteritis. Case report and literature review.

Context: Eosinophilic gastroenteritis is characterized by eosinophilic infiltration of any gastrointestinal segment from the esophagus to the rectum, most commonly, the stomach and the duodenum. Clinical manifestations range from non-specific gastrointestinal complaints to more specific symptoms such as protein-losing enteropathy, malabsorption, luminal obstruction and eosinophilic ascites.

Case Report: We report the case of a 35-year-old woman with recurrent gastric outlet obstruction due to eosinophilic infiltration of the stomach and the duodenum.