Publications by authors named "Magnolia M da Silva"
Background: Education is believed to contribute positively to brain structure and function, as well as to cognitive reserve. One of the brain regions most impacted by education is the medial temporal lobe (MTL), a region that houses the hippocampus, which has an important role in learning processes and in consolidation of memories, and is also known to undergo neurogenesis in adulthood. We aimed to investigate the influence of education on the absolute cell numbers of the MTL (comprised by the hippocampal formation, amygdala, and parahippocampal gyrus) of men without cognitive impairment.
View Article and Find Full Text PDFBackground: Depression has been associated with dementia. This study aimed to verify if β-amyloid Alzheimer's disease-type burden was associated with lifetime major depressive disorder (MDD) and with current depressive symptoms in a large population-based autopsy study.
Methods: We included 1013 deceased subjects submitted to autopsy (mean age=74.
Background: Diabetes mellitus is a risk factor for dementia, especially for vascular dementia (VaD), but there is no consensus on diabetes as a risk factor for Alzheimer's disease (AD) and other causes of dementia.
Objective: To explore the association between diabetes and the neuropathological etiology of dementia in a large autopsy study.
Methods: Data were collected from the participants of the Brain Bank of the Brazilian Aging Brain Study Group between 2004 and 2015.
Background: Previous evidence linking diabetes to Alzheimer's disease (AD) neuropathology is mixed and scant data are available from low- and middle-income countries.
Objective: To investigate the association between diabetes and AD neuropathology in a large autopsy study of older Brazilian adults.
Methods: In this cross-sectional study, diabetes was defined by diagnosis during life or use of antidiabetic medication.