What importance do donors and recipients attribute to the nuclear DNA-related genetic heritage of oocyte donation?

Study Question: How do oocyte donors and recipients perceive the genetic link related to the transfer of nuclear DNA between donors and offspring?

Summary Answer: Whether they are donors or recipients, individuals attach great importance to the transmission of their genetic heritage, since 94.5% would opt for the pronuclear transfer method to preserve this genetic link in the context of oocyte donation.

What Is Known Already: Since 1983, the use of oocyte donation has increased worldwide.

The importance of on-site genetic counseling for prospective assisted reproductive technology patients.

Purpose: To assess the value of having an onsite genetic counseling service integrated into an assisted reproductive technology (ART) center.

Methods: Since January 2021, we have offered genetic counseling at our ART center for couples whose medical history suggests risk of transmission of a genetic disorder. The percentage of couples referred for genetic counseling, the distribution of couples according to reasons for consultation, the mode of transmission in cases of Mendelian disorders, and the frequency of mutations for those with identified genetic disorders were determined.

[Fertility preservation in transgender people].

Most of transgender people plan to have a family but their fertility may be affected by gender affirmation. Hormone therapy can permanently affect gamete production, especially in trans women. Sex reassignment surgery leads to permanent sterility.

Impact of nuclearity and topology on the single molecule magnet behaviour of hexaazatrinaphtylene-based cobalt complexes.

A hexaazatrinaphtylene-based transition metal complex that exhibits single molecule magnet (SMM) behaviour is reported herein. Both monometallic (1) and bimetallic (2) CoII complexes with distorted octahedral geometries could be obtained through a straightforward change in synthetic conditions. Field induced SMM behaviour was exhibited by 1, with a D value of -60 cm-1 and Ueff = 17 K originating from the unquenched orbital angular momentum of the octahedral CoII (d7) centre.

Organic Thin Film Transistors Incorporating Solution Processable Thieno[3,2-b]thiophene Thienoacenes.

Bottom-gate bottom-contact organic thin film transistors (OTFTs) were prepared with four novel star-shaped conjugated molecules containing a fused thieno[3,2-]thiophene moiety incorporated either in the core and/or at the periphery of the molecular framework. The molecules were soluble in CS₂, allowing for solution-processing techniques to be employed. OTFTs with different channel geometries were characterized in both air and vacuum in order to compare environmental effects on performance.

Indium@silica core-shell nanoparticles as plasmonic enhancers of molecular luminescence in the UV region.

Large fluorescence enhancement of UV-active molecular models Carbostyril 124 and tryptophan by core-shell indium-based plasmonic architectures demonstrates the metal's potential in the design of bioprobes. Precise control over the metal-fluorophore distance is achieved through the controlled deposition of a uniform silica layer over the nanosized indium particles.

Mutations in AtCML9, a calmodulin-like protein from Arabidopsis thaliana, alter plant responses to abiotic stress and abscisic acid.

Many stimuli, such as hormones and abiotic stress factors, elicit changes in intracellular calcium levels that serve to convey information and activate appropriate responses. The Ca2+ signals are perceived by different Ca2+ receptors, and calmodulin (CaM) is one of the best-characterized Ca2+ sensors in eukaryotes. Calmodulin-like (CML) proteins also exist in plants; they share sequence similarity with the ubiquitous and highly conserved CaM, but their roles at the physiological and molecular levels are largely unknown.

[Spinal cord compression caused by extramedullary hematopoiesis foci in the course of thalassemia].

Background: Extramedullary haematopoiesis is a physiological response to chronic anemia, observed frequently during homozygous thalassemia. It is usually asymptomatic but can be manifested by compression of adjacent organs, particularly the spinal cord.

Case Report: A 44-year-old woman diagnosed with thalassaemia intermedia, was admitted for difficulties to walk and sphincter disturbances.

[C-reactive protein in inflammatory articular diseases: comparison of concentrations in blood and synovial fluid].

We evaluated the diagnostic value of measuring C-Reactive Protein (CRP) in blood and in synovial fluid for the detection of inflammatory articular diseases in 154 patients. High concentrations of CRP in blood were found in microcrystalin arthritis, polymyalgia rheumatica and Horton's disease. Our results show a good correlation between CRP and erythrocyte sedimentation rate for ankylosing spondylitis (p less than 0.