Long-term assessment of anti-SARS-CoV-2 antibody levels post-pandemic: Tracking the dynamics after two, three, and four COVID-19 vaccine doses.

Background: Given the limited available data about to the number of vaccine doses administered over an extended time in Iran, the immune status of vaccinated individuals and any potential disparities in this regard among those who received different numbers of vaccine doses remain unknown. Therefore, this study aimed to assess humoral immunity of individuals who received different doses of the COVID-19 vaccines in Iran.

Methods: This study was conducted from February, 2022 to December 2023 including 605 vaccinated subjects.

Psychometric properties of the Iranian version of the dissociative experiences measure, Oxford (DEMO).

Backgrounds: Dissociative experiences are described as crucial psychological mechanisms involving the organism's responses to severe psychological traumas and unpleasant past experiences. This research was conducted to examine the psychometric properties of the Dissociative Experiences Measure, Oxford (DEMO) in the Iranian general population.

Methods: This study used cross-sectional correlation, and the statistical population consisted of Iranians over 15 years old.

Investigating the psychometric properties of the Persian version of the Quality of Life Questionnaire for Women Infected with HPV (EQUALI-HPV).

Introduction: People with human papiloma virus (HPV) struggle with numerous challenges and needs in physical, and psychological aspects of quality of life related to this virus. Several studies have recommended counseling interventions to improve the quality of life for these individuals. There is also a need for standardized and normalized instruments in Iran to evaluate the effect of educational and therapeutic interventions on the quality of life of these patients.

Adenylyl Cyclase Isoform 6 in the Pulmonary Artery Is Inhibited by Hypoxia via Cysteine Nitrosylation.

Persistent pulmonary hypertension of the newborn (PPHN) is a hypoxic disorder of pulmonary vascular relaxation, mediated in part by adenylyl cyclase (AC). Neonatal pulmonary arteries (PA) express mainly AC6 isoform, followed by AC3, 7 and 9. AC6 expression is upregulated in hypoxia.

Development of a sensitive ds-DNA/Au NPs/ PGE biosensor for determination of Buprenorphine using electrochemical and molecular dynamic simulation investigation.

A sensitive electrochemical DNA biosensor has been developed for the detection of Buprenorphine (Bu), a narcotic pain reliever. To achieve this, double-stranded DNA (ds-DNA) was immobilized on a pencil graphite electrode that was modified with gold nanoparticles (Au NPs/PGE). The gold nanoparticles enhanced the performance of the DNA biosensor.

Adenylyl cyclase isoforms 5 and 6 in the cardiovascular system: complex regulation and divergent roles.

Adenylyl cyclases (ACs) are crucial effector enzymes that transduce divergent signals from upstream receptor pathways and are responsible for catalyzing the conversion of ATP to cAMP. The ten AC isoforms are categorized into four main groups; the class III or calcium-inhibited family of ACs comprises AC5 and AC6. These enzymes are very closely related in structure and have a paucity of selective activators or inhibitors, making it difficult to distinguish them experimentally.

Preparation of nanostructured photocatalyst ZnSnO@S-doped g-CN and its use in DB1 dye degradation through photocatalytic ozonation process.

This study aimed to investigate the potential of the photocatalytic ozonation process (PCO) for decolorizing DB1(direct blue) dye, a commonly used dye in the textile industry known for its resistance to removal from wastewater. To address this challenge, a ZnSnO@S-doped g-CN nano photocatalyst was synthesized using a simple hydrothermal method. In a novel approach, a light/O/ZnSnO@S-doped g-CN system was employed for the first time to degrade the DB1 dye.

Injection cessation and relapse to injection and the associated factors among people who inject drugs in Iran: The Rostam study.

Background: Drug injection is a major health-related problem worldwide. Injection cessation and relapse to injection could significantly alter the risk of HIV and hepatitis C virus (HCV) among people who inject drugs (PWID). This study aimed to estimate the rate of injection cessation and relapse to injection among PWID in Iran.

Improvement of salt rejection efficiency of cellulose acetate membrane through modification by poly(amidoamine) dendrimer-functionalized graphene oxide.

In this work, the grafting method using graphene oxide (GO) - poly(amidoamine) dendrimer (PAMAM) nanocomposite as filler for the functionalization of cellulose acetate membrane is reported. Here, cellulose acetate membrane incorporated by nanocomposite in the polymer solution was prepared through the phase inversion technique. The effect of embedding GO-PAMAM on the characterization properties and rejection performance was studied.

Development of bismuth sulfide nanorods and polyamidoamine dendrimer on reduced graphene oxide as electrode nanomaterials for electrochemical determination of salbutamol.

Dendrimers, a new class of nanomaterials, are receiving more attention in various fields. In this study, by combining the advantages of polyamidoamine (PAMAM) dendrimer with reduced graphene oxide (rGO) and bismuth sulfide (BiS), we came to design a new composite and its application for electrochemical sensors was investigated for the first time. As a new approach in the preparation of the composite, PAMAM was used for the first time to increase the surface of BiS with rGO, which ultimately led to an increase in the active surface area of the sensor (5 times compared to the bare electrode).

Molybdenum Disulfide/Nickel-Metal Organic Framework Hybrid Nanosheets Based Disposable Electrochemical Sensor for Determination of 4-Aminophenol in Presence of Acetaminophen.

The toxicity of commonly used drugs, such as acetaminophen (ACAP) and its degradation-derived metabolite of 4-aminophenol (4-AP), underscores the need to achieve an effective approach in their simultaneous electrochemical determination. Hence, the present study attempts to introduce an ultra-sensitive disposable electrochemical 4-AP and ACAP sensor based on surface modification of a screen-printed graphite electrode (SPGE) with a combination of MoS nanosheets and a nickel-based metal organic framework (MoS/Ni-MOF/SPGE sensor). A simple hydrothermal protocol was implemented to fabricate MoS/Ni-MOF hybrid nanosheets, which was subsequently tested for properties using valid techniques including X-ray diffraction (XRD), field emission-scanning electron microscopy (FE-SEM), energy dispersive X-ray spectroscopy (EDX), Fourier transformed infrared spectroscopy (FTIR), and N adsorption-desorption isotherm.

Development of doxorubicin-encapsulated magnetic liposome@PEG for treatment of breast cancer in BALB/c mice.

The magnetic doxorubicin-encapsulated liposome/PEG/FeO (called as DOX@m-Lip/PEG) was synthesized and studied as a novel nanocarrier for the treatment of breast cancer in BALB/c mice. Nanocarrier was characterized by FT-IR, zeta-potential sizer, EDX elemental analysis, EDX mapping, TEM, and DLS techniques. The results showed that the size of the nanocarrier was determined around 128 nm by TEM.

Characterization of Adenylyl Cyclase Isoform 6 Residues Interacting with Forskolin.

Background: The adenylyl cyclase (AC) pathway, crucial for pulmonary vasodilation, is inhibited by hypoxia. Forskolin (FSK) binds allosterically to AC, stimulating ATP catalysis. As AC6 is the primary AC isoform in the pulmonary artery, selective reactivation of AC6 could provide targeted reinstatement of hypoxic AC activity.

Electrospun nanofibers of cellulose acetate/metal organic framework-third generation PAMAM dendrimer for the removal of methylene blue from aqueous media.

In this research, magnetic metal-organic framework nanofibers were produced by the electrospinning method. The nanocomposite was functionalized by third generation hyperbranched poly(amidoamine) dendrimer (PAMAM) to improve its dye adsorption efficiency from aqueous media. The characteristics of the synthesized magnetic nanocomposite was determined by Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy (EDS) along with elemental mapping analysis and scanning electron microscopy (SEM).

The Effect of a Healthcare Services Hotline on Quality of Life and Hospital Readmissions for Patients with Chronic Obstructive Pulmonary Disease.

Chronic obstructive pulmonary disease (COPD) is a common debilitating disease marked by frequent exacerbations and hospitalizations, economic burden, and reduced quality of life. This study aimed to determine the effect of a healthcare hotline on quality of life and hospital readmissions within 30 days of discharge for patients with COPD. Sixty patients with COPD who needed home healthcare services were recruited for this quasi-experimental study.

SnO@ZnO nanocomposites doped polyaniline polymer for high performance of HTM-free perovskite solar cells and carbon-based.

Herein, at first, green SnO@ZnO nanocomposites were synthesized using Calotropis plant extract as an electron transfer material (ETM) to fabricate low-temperature-processed perovskite solar cells (PSCs). Then, the polyaniline (PANI) polymer was applied as an efficient additive to improve perovskite film quality. Under the effects of the small content of PANI additive, the quality of perovskite films is enhanced, which showed higher crystallinity in (110) crystal plane; also, the perovskite grains were found to be enlarged from 342 to 588 nm.

Effective visible-light-driven photocatalytic degradation of fenitrothion by s-gCN/Ag-Au bimetallic nanocomposite.

This paper reports on the optimization of fenitrothion photocatalytic degradation in visible light based on Plackett Burman (PB) design and central composite design (CCD) in response surface methodology (RSM). A herbicide routinely used with a negative impact on the environment is fenitrothion, which must be degraded to minimize the impact on the environment. For fenitrothion degradation, Ag-Au bimetallic nanoparticles on the semiconducting s-doped gCN surface were synthesized using the galvanic exchange.

A review on computer-aided chemogenomics and drug repositioning for rational COVID-19 drug discovery.

Application of materials capable of energy harvesting to increase the efficiency and environmental adaptability is sometimes reflected in the ability of discovery of some traces in an environment-either experimentally or computationally-to enlarge practical application window. The emergence of computational methods, particularly computer-aided drug discovery (CADD), provides ample opportunities for the rapid discovery and development of unprecedented drugs. The expensive and time-consuming process of traditional drug discovery is no longer feasible, for nowadays the identification of potential drug candidates is much easier for therapeutic targets through elaborate in silico approaches, allowing the prediction of the toxicity of drugs, such as drug repositioning (DR) and chemical genomics (chemogenomics).

Porphyrin Molecules Decorated on Metal-Organic Frameworks for Multi-Functional Biomedical Applications.

Metal-organic frameworks (MOFs) have been widely used as porous nanomaterials for different applications ranging from industrial to biomedicals. An unpredictable one-pot method is introduced to synthesize NH-MIL-53 assisted by high-gravity in a greener media for the first time. Then, porphyrins were deployed to adorn the surface of MOF to increase the sensitivity of the prepared nanocomposite to the genetic materials and in-situ cellular protein structures.

8-Alkylmercaptocaffeine derivatives: antioxidant, molecular docking, and in-vitro cytotoxicity studies.

Due to their unique pharmacological characteristics, methylxanthines are known as therapeutic agents in a fascinating range of medicinal scopes. In this report, we aimed to examine some biological effects of previously synthesized 8-alkylmercaptocaffeine derivatives. Cytotoxic and antioxidative activity of 8-alkylmercaptocaffeine derivatives were measured in malignant A549, MCF7, and C152 cell lines.

The colorful world of carotenoids: a profound insight on therapeutics and recent trends in nano delivery systems.

The therapeutic effects of carotenoids as dietary supplements to control or even treat some specific diseases including diabetic retinopathy, cardiovascular diseases, bacterial infections, as well as breast, prostate, and skin cancer are discussed in this review and also thoughts on future research for their widespread use are emphasized. From the stability standpoint, carotenoids have low bioavailability and bioaccessibility owing to their poor water solubility, deterioration in the presence of environmental stresses such as oxygen, light, and high heat as well as rapid degradation during digestion. Nanoencapsulation technologies as wall or encapsulation materials have been increasingly used for improving food product functionality.

Ultraviolet protection of Bacillus thuringiensis through microencapsulation with Pickering emulsion method.

An encapsulated formulation of Bacillus thuringiensis (Bt) was produced by the Pickering emulsion technique to improve its activity and stability under UV-A radiation. In this technique latex particles, GO nanosheets, olive oil, ethanol, and water were used to encapsulate Bt in colloidosomes. The protective efficacy of this formulation in protecting Bt subsp.

Burgeoning Polymer Nano Blends for Improved Controlled Drug Release: A Review.

With continual rapid developments in the biomedical field and understanding of the important mechanisms and pharmacokinetics of biological molecules, controlled drug delivery systems (CDDSs) have been at the forefront over conventional drug delivery systems. Over the past several years, scientists have placed boundless energy and time into exploiting a wide variety of excipients, particularly diverse polymers, both natural and synthetic. More recently, the development of nano polymer blends has achieved noteworthy attention due to their amazing properties, such as biocompatibility, biodegradability and more importantly, their pivotal role in controlled and sustained drug release in vitro and in vivo.