Publications by authors named "Maggie W Lee"
Article Synopsis
- - SARS-CoV-2, the virus behind COVID-19, uses proteases like TMPRSS2 to enter human cells by cleaving its spike protein, but targeting just one protease may not completely block infection.
- - The study identified multiple amino acid sequences in the spike protein that are vulnerable to cleavage by additional proteases such as furin and various cathepsins, using the PACMANS computational platform for analysis.
- - Findings suggest that cathepsins B, K, L, S, and V could play significant roles in SARS-CoV-2 infection, indicating a need for further research on these proteases, especially in the context of inflammatory conditions that can worsen COVID-19 outcomes.
Human preterm labor (PL) is the single most significant problem in modern Obstetrics and Gynecology, affecting approximately 10% of pregnancies worldwide, constituting the leading cause of perinatal mortality and morbidity, and contributing significantly to chronic childhood disease. Currently, our molecular understanding of PL remains staggeringly inadequate to reliably diagnose or rationally intervene in PL events; several molecular alterations have been implicated in PL, but these have proven of limited value as diagnostic/prognostic markers. The majority of PL events remain spontaneous and unpredictable: critical care emergencies.
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