Publications by authors named "Maggie R Lesley"
Study Objective: To determine if the use of ultrasound guidance (vs non-ultrasound techniques) improves the success rate of nerve blocks.
Design: Meta-analysis of randomized controlled trials (RCTs) in the published literature.
Setting: University medical center.
Article Synopsis
- Extended-release epidural morphine (EREM) is designed for postoperative pain relief lasting 48 hours, but its safety concerning respiratory depression compared to intravenous patient-controlled analgesia (IV-PCA) is unclear and prompted a meta-analysis.
- A systematic search of literature identified three qualifying randomized controlled trials that evaluated the rates of respiratory depression between EREM and IV-PCA using a random effects model for analysis.
- The findings revealed that EREM is significantly associated with higher odds of respiratory depression compared to IV-PCA, indicating that while EREM is effective for pain relief, it poses increased risk for respiratory issues.
Background And Objectives: Painful diabetic peripheral neuropathy (DPN) is an increasingly prevalent disorder that is best managed through a multimodal approach. We examined the effects of pregabalin on pain control, sleep disturbance, and the patient's global impression of change (PGIC) for the treatment of this disorder.
Methods: Studies were identified using the National Library of Medicine's PubMed and EMBase databases (1966 to July 15, 2007).