Publications by authors named "Maggie O Goodson"
Article Synopsis
- Ceramide-induced mitochondrial fission plays a key role in obesity caused by a high-fat diet (HFD), but existing treatments targeting mitochondrial dynamics have been largely ineffective in animal models.
- New findings show that the synthetic sphingolipid SH-BC-893 can quickly prevent ceramide-induced mitochondrial disruptions by targeting specific endolysosomal trafficking processes.
- Administration of SH-BC-893 in mice on a HFD not only improved mitochondrial function and normalized organ morphology within hours but also corrected metabolic issues like body weight, glucose disposal, and fat levels.
Lung adenocarcinoma is associated with cachexia, which manifests as an inflammatory response that causes wasting of adipose tissue and skeletal muscle. We previously reported that lung tumor-bearing (TB) mice exhibit alterations in inflammatory and hormonal signaling that deregulate circadian pathways governing glucose and lipid metabolism in the liver. Here, we define the molecular mechanism of how de novo glucose production in the liver is enhanced in a model of lung adenocarcinoma.
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