Publications by authors named "Magee L"

Problem And Background: During the COVID-19 pandemic, there was substantial reconfiguration of maternity care services, affecting both users and healthcare providers (HCPs), in the United Kingdom (UK) and globally.

Aim: To further our understanding of the impact of maternity service reconfigurations in the UK, from the perspective of maternity HCPs.

Methods: Scopus, MEDLINE, EMBASE, CINAHL, PsycINFO and the Cochrane COVID Study Register were searched for relevant studies reporting qualitative data from the UK, published in English between 01 June 2021 and 30 September 2023.

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Background: Social determinants of health have been shown to influence individual mental health and overall well-being. Additionally, populations that experience stigma and/or discrimination because of race, class, gender, or another identity group experience disproportionately higher rates of mental health disorders than populations that do not experience such marginalization. One way to address upstream social determinants that influence mental health is through systems change initiatives.

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Article Synopsis
  • Chronic or gestational hypertension affects about 7% of pregnancies, and the WILL Trial aimed to find the best timing for delivery to improve outcomes for mothers and babies.
  • The trial involved women with hypertension at 36 to 37 weeks gestation who were randomly assigned to either an early delivery intervention at 38 weeks or usual care at term, analyzing maternal and neonatal outcomes.
  • Despite aiming for 540 participants, the trial ended early with only 403 participants due to slow recruitment, showing no significant difference in poor maternal outcomes between the two groups, while deliveries in the intervention group occurred about 0.9 weeks earlier.
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Conspecific density dependence (CDD) in plant populations is widespread, most likely caused by local-scale biotic interactions, and has potentially important implications for biodiversity, community composition, and ecosystem processes. However, progress in this important area of ecology has been hindered by differing viewpoints on CDD across subfields in ecology, lack of synthesis across CDD-related frameworks, and misunderstandings about how empirical measurements of local CDD fit within the context of broader ecological theories on community assembly and diversity maintenance. Here, we propose a conceptual synthesis of local-scale CDD and its causes, including species-specific antagonistic and mutualistic interactions.

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Maternal vaccination during pregnancy, in general and against COVID-19 infection, offers protection to both mother and baby, but uptake remains suboptimal. This study aimed to explore the perceptions regarding COVID-19 vaccination in pregnancy, particularly for marginalised populations and those living with social or medical complexity. A total of 96 semi-structured in-depth interviews were conducted with 40 women, 15 partners, 21 HCPs, and 20 policy makers, across all four nations of the United Kingdom (UK), discussing their lived experience of utilising, delivering, or developing policy for COVID-19 vaccination in pregnancy during the pandemic.

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When surgically managing cholesteatoma, the Bondy modified radical mastoidectomy (MRM) and retrograde mastoidectomy can enhance visualization while minimizing the extent of surgery required for disease removal. The Bondy MRM can be used for disease limited to the atticoantral space, when the ossicles and middle ear space are otherwise healthy, and for canal cholesteatomas. The retrograde mastoidectomy offers a safe alternative for patients with unfavorable tegmen and sigmoid sinus positions and poorly pneumatized mastoids.

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Introduction: Healthcare services for pregnant and postpartum ('perinatal') women were reconfigured significantly at the advent and for the duration of the SARS-CoV-2 pandemic, and despite the United Kingdom announcing 'Freedom Day' on 19 July 2021 (whereafter all legal lockdown-related restrictions were lifted), restrictions to maternity (antenatal, intrapartum, and postnatal) services remained. This study presents data from eight perinatal women about their experiences of psychosocial wellbeing and maternity care in the post-'Freedom Day' epoch.

Methods: Semi-structured interviews were conducted virtually, with data recorded, transcribed, and analysed by hand.

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Article Synopsis
  • The study aims to investigate the rising cesarean section rates in Greece and implement interventions to promote vaginal delivery through a trial named ENGAGE, focusing on evidence-based practices.
  • Twenty-two maternity units across Greece will participate in a multicenter trial involving 20,000 to 25,000 births, employing a stepped-wedge design whereby units will gradually implement interventions over 8-18 months.
  • Key interventions include applying updated clinical guidelines, training on cardiotocography, and providing ongoing support to healthcare professionals, with data on cesarean rates and outcomes collected for analysis throughout the study.
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Background: Women who suffer an early pregnancy loss require specific clinical care, aftercare, and ongoing support. In the UK, the clinical management of early pregnancy complications, including loss is provided mainly through specialist Early Pregnancy Assessment Units. The COVID-19 pandemic fundamentally changed the way in which maternity and gynaecological care was delivered, as health systems moved to rapidly reconfigure and re-organise services, aiming to reduce the risk and spread of SARS-CoV-2 infection.

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Background: Testing positive for COVID-19 was associated with higher rates of detrimental psycho-social and physical health outcomes. The COVID-19 pandemic caused unprecedented disruption to everyday life. This included major reconfiguration of maternal, child, and perinatal mental health and care services and provision.

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The ecology of forest ecosystems depends on the composition of trees. Capturing fine-grained information on individual trees at broad scales provides a unique perspective on forest ecosystems, forest restoration, and responses to disturbance. Individual tree data at wide extents promises to increase the scale of forest analysis, biogeographic research, and ecosystem monitoring without losing details on individual species composition and abundance.

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Background: In high-resource settings, biomarkers of angiogenic balance, such as the soluble fms-like tyrosine kinase-1 (sFlt1)/placental growth factor (PlGF) ratio, have been studied extensively to aid in evaluation of patients with suspected preeclampsia (PE), and have been incorporated into the 2021 International Society for the Study of Hypertension in Pregnancy definition of PE. The utility in under-resourced settings has not been as well characterized.

Objective: This analysis sought to identify the role of the sFlt1/PlGF ratio in the evaluation of patients with or without hypertension who are suspected of having PE without other diagnostic information.

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Introduction: The burden of severe maternal morbidity is highest in sub-Saharan Africa, and its relative contribution to maternal (ill) health may increase as maternal mortality continues to fall. Women's perspective of their long-term recovery following severe morbidity beyond the standard 42-day postpartum period remains largely unexplored.

Methods: This woman-centred, grounded theory study was nested within the Pregnancy Care Integrating Translational Science Everywhere (PRECISE) study in Kilifi, Kenya.

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Article Synopsis
  • Positive and negative interactions among species shape the assembly of communities, particularly in dryland plant ecosystems like southeastern U.S. savannas.
  • A study of longleaf pine and sandhill oaks revealed that higher oak densities significantly increased the survival and growth rates of longleaf pine seedlings, while lowest recruitment occurred under longleaf pine canopies.
  • The findings suggest that conserving and managing xeric oaks can enhance the recovery and sustainability of longleaf pine ecosystems, which are vital for global biodiversity.
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  • When plants die, it helps nearby plants by reducing competition for resources like sunlight and nutrients.
  • In a study of 37,212 trees, scientists found that dead trees (legacy effects) had a much stronger impact on the growth and survival of neighboring trees than the living ones.
  • Most tree species were negatively affected by the presence of dead trees, which shows that the past presence of these trees can change how plant communities work.
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Background: PRECISE-DYAD is an observational cohort study of mother-child dyads running in urban and rural communities in The Gambia and Kenya. The cohort is being followed for two years and includes uncomplicated pregnancies and those that suffered pregnancy hypertension, fetal growth restriction, preterm birth, and/or stillbirth.

Methods: The PRECISE-DYAD study will follow up ~4200 women and their children recruited into the original PRECISE study.

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Background: A parallel has been drawn between first-trimester placental vascular maturation and maternal cardiovascular adaptations, including blood pressure. Although 140/90 mm Hg is well-accepted as the threshold for chronic hypertension in the general obstetric population in early pregnancy, a different threshold could apply to stratify the risk of adverse outcomes, such as preeclampsia. This could have implications for interventions, such as the threshold for initiation of antihypertensive therapy and the target blood pressure level.

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COVID-19 vaccination rates are lower in women of reproductive age (WRA), including pregnant/postpartum women, despite their poorer COVID-19-related outcomes. We evaluated the vaccination experiences of 3568 U.K.

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Objective: Children with craniofacial microsomia (CFM) have complex healthcare needs, resulting in evaluations and interventions from infancy onward. Yet, little is understood about families' treatment experiences or the impact of CFM on caregivers' well-being. To address this gap, the NIH-funded 'Craniofacial microsomia: Accelerating Research and Education (CARE)' program sought to develop a conceptual thematic framework of caregiver adjustment to CFM.

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Background: Affecting 2-4% of pregnancies, pre-eclampsia is a leading cause of maternal death and morbidity worldwide. Using routinely available data, we aimed to develop and validate a novel machine learning-based and clinical setting-responsive time-of-disease model to rule out and rule in adverse maternal outcomes in women presenting with pre-eclampsia.

Methods: We used health system, demographic, and clinical data from the day of first assessment with pre-eclampsia to predict a Delphi-derived composite outcome of maternal mortality or severe morbidity within 2 days.

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