Publications by authors named "Maged Z"

We present images of a 50-year-old man who referred for treatment of a classic Hodgkin lymphoma. While F-FDG PET/CT demonstrated a complete metabolic remission after chemotherapy, an increased F-FDG uptake of a right testicular lesion in F-FDG PET/CT and an unexplained bilateral gynecomastia were observed. A benign Leydig cell tumor was histopathologically proved after a right radical orchiectomy.

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The immunomodulating properties of antimicrobial drugs may have important implications in prescriptive practice. This is particularly so for patients whose immune system has been compromised. In this study, tetracycline, cephalothin, rifampicin, polymyxin B and nitrofurantoin reduced mitogen responsiveness of both B and T lymphocytes of mouse spleen cells and human peripheral blood lymphocytes in vitro in a dose-dependent fashion.

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Thirty-five infants and children with beta-thalassemia major and 12 with beta-thalassemia trait were studied. Their ages ranged between 6 months and 12 years. Thirty-three were males and 14 females.

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Article Synopsis
  • The study investigated how various antibiotics affect immune functions, focusing on natural killer (NK) cell activity, antibody dependent cell-mediated cytotoxicity (ADCC), and immunoglobulin production.
  • Nitrofurantoin was found to significantly reduce NK activity in a dose-dependent manner but did not affect spontaneous ADCC, although it did suppress interferon-enhanced ADCC.
  • Other antibiotics, including chloramphenicol, tetracycline, and rifampicin, were shown to decrease immunoglobulin synthesis, highlighting potential clinical implications for treating immunocompromised patients.
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Article Synopsis
  • In a study involving 25 patients with homozygous beta thalassemia and 7 with the trait, serum levels of IgG, IgM, and IgA were found to be elevated in those with homozygous beta thalassemia, particularly after undergoing splenectomy.
  • Homozygous beta thalassemia patients showed impaired serum opsonic activity against Salmonella typhi and staphylococci, with additional impairment observed against salmonella post-splenectomy.
  • Phagocytic activity against both bacteria was reduced in beta thalassemia patients, and splenectomy further decreased the effectiveness against salmonella, while those with the thalassemia trait showed immune responses
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Twenty-one cases of acute glomerulonephritis in children with no previous history of renal disease were studied. Urinary infection with a rising titre of serum agglutinins against the organisms isolated from urine was found in 5 cases. No evidence of previous streptococcal infection was found in these cases.

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