Posterior reversible encephalopathy syndrome in children with malignancies - a single-center retrospective study.

Background: Posterior reversible encephalopathy syndrome (PRES) diagnosis relies on clinical and radiological characteristics. Clinical manifestations include focal neurologic deficits, hemiparesis, seizures with symptoms of intracranial hypertension, headache, nausea, vomiting, and visual field disturbances. The majority of patients have typical changes in magnetic resonance imaging.

Can CD34CD38 lymphoblasts, as likely leukemia stem cells, be a prognostic factor in B-cell precursor acute lymphoblastic leukemia in children?

Background: CD34CD38 lymphoblasts as likely leukemia stem cells (LSCs) may be responsible for a worse response to treatment and may be a risk factor for recurrence in B-cell precursor acute lymphoblastic leukemia (BCP-ALL).

Objective: The study objective was to assess the prognostic role of CD34CD38 lymphoblasts in bone marrow on the day of BCP-ALL diagnosis.

Methods: 115 patients with BCP-ALL, the median age of 4.

Relapses Children's Acute Lymphoblastic Leukemia, Single Center Experience.

The prognosis in children and adolescents with relapsed ALL, despite intensive therapy, including hematopoietic stem cell transplantation, is still challenging. This study aims to analyze the incidence of relapsed ALL and survival rates in correlation to the risk factors. Materials and methods: 125 pediatric patients with ALL diagnosed in our department between 2000-2018; age 1−18 years old (median 6.

Hemophagocytic lymphohistiocytosis associated with ocrelizumab treatment in a patient with multiple sclerosis.

Background: Hemophagocytic lymphohistiocytosis (HLH) is a rarely recognized hyperinflammatory condition of high death risk.

Objective: The objective was to describe a case of HLH in a patient with multiple sclerosis (MS) treated with ocrelizumab.

Methods: Clinical observation, laboratory testing, and use of HLH-2004 criteria for HLH diagnosis.