A series of copper(II) complexes of 2-imino-2-chromen-3-yl-1,3,5-triazines , 3-(benzoxazol-2-yl)-2-chromen-2-imines , and 3-(benzothiazol-2-yl)-2-chromen-2-imines were obtained by reacting of appropriate 2-iminocoumarin ligands , , and with 3-fold molar excess of copper(II) chloride. The structure of these compounds was confirmed by IR spectroscopy, elemental analysis, and single-crystal X-ray diffraction data (, , , and ). All the synthesized complexes were screened for their activity against five human cancer cell lines: DAN-G, A-427, LCLC-103H, SISO, and RT-4 by using a crystal violet microtiter plate assay and relationships between structure and in vitro cytotoxic activity are discussed.
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