Impaired counterregulatory responses to hypoglycaemia following oral glucose in adults with cystic fibrosis.

Aims/hypothesis: The aim of this study was to determine the mechanism(s) for hypoglycaemia occurring late following oral glucose loading in patients with cystic fibrosis (CF).

Methods: A 3 h 75 g OGTT was performed in 27 non-diabetic adults with CF who were classified based on this test as experiencing hypoglycaemia (glucose <3.3 mmol/l with or without symptoms or glucose <3.

The antioxidant N-Acetylcysteine does not improve glucose tolerance or β-cell function in type 2 diabetes.

Unlabelled: Hyperglycemia induces oxidative stress and thereby may exacerbate β-cell dysfunction in type 2 diabetes (T2DM). Notably, glutathione (GSH), synthesized from N-Acetylcysteine (NAC), neutralizes reactive oxygen species within cells and is low in individuals with diabetes.

Aim: Determine if NAC supplementation improves β-cell function and glucose tolerance by decreasing oxidative stress in T2DM.

The use of metformin is associated with decreased lumbar radiculopathy pain.

Lumbar radiculopathy pain represents a major public health problem, with few effective long-term treatments. Preclinical neuropathic and postsurgical pain studies implicate the kinase adenosine monophosphate activated kinase (AMPK) as a potential pharmacological target for the treatment of chronic pain conditions. Metformin, which acts via AMPK, is a safe and clinically available drug used in the treatment of diabetes.