Publications by authors named "Magdalena Siekierka"
Background: Recently, polymorphisms of cytokine genes have been associated with modified gene expression and increased cytokine production. We evaluated the influence of interleukin-10 (IL-10) gene G-1082A, tumour necrosis factor alpha (TNFalpha) gene G-308A and IL-6 gene G-174C polymorphisms on the rejection rate, renal function and long-term outcome in renal transplantation.
Patients And Methods: We studied n = 224 consecutive patients, who underwent renal transplantation at our centre from 1998 to 2001 (cadaveric: n = 175, living related: n = 49) followed up for 4.
Article Synopsis
- The study examines the link between the TNF-alpha G-308A gene polymorphism and the development of membranous glomerulonephritis.
- The A-allele, associated with higher TNF-alpha levels, was more prevalent in patients than in healthy controls.
- While there was a trend indicating that the A-allele may influence disease progression, the study found no significant impact on renal survival.