Publications by authors named "Magdalena Schelotto"
International Society of Paediatric Oncology (SIOP) Global Mapping Program: Analysis of healthcare centers in countries of the Latin American Society of Pediatric Oncology (SLAOP).
Pediatr Blood Cancer
November 2024
Background: The International Society of Paediatric Oncology Society Global Mapping Program aims to describe the local pediatric oncology capacities. Here, we report the data from Latin America.
Methods: A 10-question survey was distributed among chairs of pediatric oncology services.
International Society of Paediatric Oncology (SIOP) Global Mapping Programme: Latin American Society of Pediatric Oncology (SLAOP) country-level report.
Pediatr Blood Cancer
June 2024
Article Synopsis
- - Latin American countries are making significant progress in childhood cancer care by implementing the Global Initiative for Childhood Cancer, although there’s limited continental-level data on these efforts.
- - A survey involving 19 out of 20 Latin American countries revealed that nine have national pediatric cancer control programs, and there are resources like tumor registries and fellowship training programs available in many countries.
- - Overall, improvements in child cancer treatment and survivorship are notable in the region, with a correlation between social development and the availability of comprehensive support and resources for pediatric oncology.
In Uruguay, the pediatric acute lymphoblastic leukemia (ALL) cure rate is 82.2%, similar to those reported in developed countries. However, many patients suffer adverse effects that could be attributed, in part, to genetic variability.
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- Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare type of skin cancer linked to certain immune cell abnormalities, particularly involving CD8 T cells, and its genetic causes are not fully understood.* -
- The article discusses two cases of patients with B cell Expansion with NF-κB and T cell Anergy (BENTA) disease who presented novel forms of SPTCL, showcasing distinct symptoms and genetic mutations related to their conditions.* -
- Patient 1 had recurrent infections linked to a mutation and developed SPTCL and kidney issues early in life, while Patient 2 exhibited splenomegaly and underwent a bone marrow transplant, leading to remission of SPTCL despite ongoing B
Background: Forkhead box protein 3 (FOXP3) is the master transcription factor in CD4CD25CD127 regulatory T (Treg) cells. Mutations in FOXP3 result in IPEX (immune dysregulation, polyendocrinopathy, enteropathy, X-linked) syndrome. Clinical presentation of IPEX syndrome is broader than initially described, challenging the understanding of the disease, its evolution, and treatment choice.
View Article and Find Full Text PDFBackground: The ongoing coronavirus 2019 disease (COVID-19) pandemic strained medical systems worldwide. We report on the impact on pediatric oncology care in Latin American (LATAM) during its first year.
Method: Four cross-sectional surveys were electronically distributed among pediatric onco-hematologists in April/June/October 2020, and April/2021 through the Latin American Society of Pediatric Oncology (SLAOP) email list and St Jude Global regional partners.
Article Synopsis
- * Researchers analyzed data from 50 patients, noting a median age of 7 months at disease onset and significant delays in diagnosis, along with discovering 6 new mutations in the CD40LG gene.
- * Common symptoms included pneumonia, respiratory infections, and various gastrointestinal issues, with the study documenting the largest number of infectious agents associated with this condition, enhancing insights for diagnosis and management.
IMPORTANCE trial: a provisional study-design of a single-center, phase II, double-blinded, placebo-controlled, randomized, 4-week study to compare the efficacy and safety of intranasal esketamine in chronic opioid refractory pain.
F1000Res
June 2021
Article Synopsis
- Cancer is the second leading cause of death worldwide, with a high percentage of advanced patients suffering from significant pain, and limited options for chronic pain management.
- Esketamine, a newer drug with better analgesic effects and fewer side effects than traditional opioids, has been FDA-approved for depression but never tested for chronic cancer pain.
- A proposed phase II trial will test intranasal esketamine in 120 participants with chronic opioid refractory pain to assess its effectiveness and safety, aiming to improve pain management and quality of life.
Objective: Identification of imaging prognostic parameters for early therapy personalisation to reduce treatment-related morbidity in paediatric Hodgkin lymphoma (HL). Our aim was to evaluate quantitative markers from baseline 2-[18F]fluoro-2-deoxy-d-glucose PET/CT as prognostic factors for treatment outcomes. Another goal was assessing the prognostic value of Deauville score at interim PET/CT.
View Article and Find Full Text PDFWe evaluated the outcome of 71 children with de novo acute myeloid leukemia enrolled in 2 consecutive protocols in the main pediatric hospital in Uruguay. In the LAM97 protocol (n=34), patients received, as consolidation, autologous or allogeneic hematopoietic stem cell transplantation (HSCT), depending on the availability or not of a matched sibling donor. In the LAM08 protocol (n=37), patients were stratified into risk groups, autologous HSCT was abandoned, and allogeneic HSCT was limited to intermediate-risk patients with matched sibling donor and to all patients who fulfilled the high-risk criteria.
View Article and Find Full Text PDFIn Uruguay, α-thalassemia (α-thal) mutations were introduced predominantly by Mediterranean European immigrant populations and by slave trade of African populations. A patient with anemia with hypochromia and microcytosis, refractory to iron treatment and with normal hemoglobin (Hb) electrophoresis was analyzed for α-thal mutations by multiplex gap-polymerase chain reaction (gap-PCR), automated sequencing and multiplex ligation-dependent probe amplification (MLPA) analyses. Agarose gel electrophoresis of the multiplex gap-PCR showed a band of unexpected size (approximately 700 bp) in the samples from the proband and mother.
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