Publications by authors named "Magdalena Romiszewska"
Article Synopsis
- Pyruvate kinase (PK) deficiency is a genetic disorder marked by chronic hemolytic anemia and is caused by mutations in the PKLR gene.
- Researchers studied nine Polish patients with severe anemia who had normal PK activity and discovered both known and a new mutation (c.178C > T) in the PKLR gene.
- They further analyzed two specific mutations (c.1058delAAG and c.101-1G > A), concluding that one negatively affects PK's stability and function, while the other creates a defective mRNA that leads to a severely reduced PK protein.
We prospectively examined whether surface expression of Cytokine Receptor-Like Factor 2 (CRLF2) on leukemic blasts is associated with survival and induction treatment response in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) patients. Flow cytometric analysis of bone marrow-derived leukemia cells revealed that 7.51% (29/286) of 386 pediatric BCP-ALL patients were CRLF2-positive (CRLF2pos) at diagnosis.
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