Publications by authors named "Magdalena Patrycy"
Article Synopsis
- Herpes simplex virus type 2 (HSV-2) primarily causes genital herpes but can lead to meningitis in rare cases, prompting research using a murine model to understand its effects on the central nervous system (CNS).
- The study found that the Fas and FasL pathways are activated in the CNS during HSV-2 infection, and mice lacking these pathways exhibited worse disease outcomes and higher viral loads.
- Overall, the research suggests that the Fas/FasL pathway is crucial for controlling inflammation and facilitating proper immune responses in the spinal cord during HSV-2 infection.
(1) Background: Epigallocatechin gallate (EGCG) has been recognized as a flavonoid showing antiviral activity against various types of DNA and RNA viruses. In this work, we tested if EGCG-modified silver nanoparticles (EGCG-AgNPs) can become novel microbicides with additional adjuvant properties to treat herpes infections. (2) Methods: The anti-HSV and cytotoxic activities of EGCG-AgNPs were tested in human HaCaT and VK-2-E6/E7 keratinocytes.
View Article and Find Full Text PDFBackground: Skeletal muscle regeneration is a complex process regulated by many cytokines and growth factors. Among the important signaling pathways regulating the myogenic cell identity are these involving SDF-1 and NOTCH. SDF-1 participates in cell mobilization and acts as an important chemoattractant.
View Article and Find Full Text PDFNeuroinflammation is defined as an inflammatory state within the central nervous system (CNS). Microglia conprise the resident tissue macrophages of the neuronal tissue. Upon viral infection of the CNS, microglia become activated and start to produce inflammatory mediators important for clearance of the virus, but an excessive neuroinflammation can harm nearby neuronal cells.
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