Development of a thin layer chromatography method for plasma correction of [F]fluorocholine metabolites in positron emission tomography quantification studies in humans.

Introduction: After its intravenous injection, [F]fluorocholine is oxidized by choline-oxidase into its main plasma metabolite, [F]fluorobetaine. If PET kinetic modeling quantification of [F]fluorocholine uptake is intended, the plasma input time-activity-curve of the parent tracer must be obtained, i.e.