HIV screening and linkage to care in a health department in Valencia, Spain: Lessons learned from a healthcare quality improvement project.

Spain's rate of new human immunodeficiency virus (HIV) diagnoses exceeds that of the European Economic Area average (8.6 vs 5.6:100,000 in 2018).

Gender gaps in research productivity and recognition among elite scientists in the U.S., Canada, and South Africa.

This study builds upon the literature documenting gender disparities in science by investigating research productivity and recognition among elite scientists in three countries. This analysis departs from both the general comparison of researchers across organizational settings and academic appointments on one hand, and the definition of "elite" by the research outcome variables on the other, which are common in previous studies. Instead, this paper's approach considers the stratification of scientific careers by carefully constructing matched samples of men and women holding research chairs in Canada, the United States and South Africa, along with a control group of departmental peers.

Analysis of the subunit organization of the eIF2B complex reveals new insights into its structure and regulation.

Eukaryotic initiation factor 2B (eIF2B) is the guanine nucleotide exchange factor for eIF2 and a critical regulator of protein synthesis, (e.g., as part of the integrated stress response).

Relationships between leisure participation and quality of life of people with developmental disabilities.

Background: Studies of people with developmental disabilities suggest that participation in leisure activities might be a key factor for good quality of life. This study explores the relationships between objective and subjective quality of life and leisure participation of adults with developmental disabilities.

Materials And Methods: A cross-sectional design was used with a convenience sample of 125 people, aged 17-65, living in the community.

Large-scale production of membrane proteins in Pichia pastoris: the production of G protein-coupled receptors as a case study.

One of the major advantages of using Pichia pastoris is that it is readily adapted to large-scale culture in bioreactors. Bioreactors allow precise regulation of cell growth parameters increasing both yields and reproducibility of the culture. P.

Screening for high-yielding Pichia pastoris clones: the production of G protein-coupled receptors as a case study.

Pichia pastoris is an established host for the production of a wide range of recombinant proteins including membrane proteins. The system has a particularly good track record for the production of G protein-coupled receptors (GPCRs). Generation and screening of expression clones with this system use standard molecular biology techniques.

Personal factors and perceived barriers to participation in leisure activities for young and adults with developmental disabilities.

Participation in leisure activities has been identified as a factor that favors inclusion in the community and it also contributes to a better quality of life. This study analyzed the influence of certain personal characteristics and environmental factors in the participation in leisure activities of youngsters and adults with developmental disabilities. A cross-sectional design was used with a convenience sample of 237 people, aged 17-65, living in the community.

Large-scale functional expression of WT and truncated human adenosine A2A receptor in Pichia pastoris bioreactor cultures.

Background: The large-scale production of G-protein coupled receptors (GPCRs) for functional and structural studies remains a challenge. Recent successes have been made in the expression of a range of GPCRs using Pichia pastoris as an expression host. P.