In this study, a new series of and 5-substituted-3-(dibenzyloxyphosphoryl)isoxazolidines - were synthesized by the 1,3-dipolar cycloaddition reaction of -benzyl--(dibenzyloxyphosphoryl)nitrone and selected -allyl--benzylquinazoline-2,4-diones. All the obtained -isoxazolidines - and the samples enriched in respective -isomers were evaluated for anticancer activity against three tumor cell lines. All the tested compounds exhibited high activity against the prostate cancer cell line (PC-3).
View Article and Find Full Text PDFDipolar cycloaddition of the N-substituted -(diethoxyphosphonyl)nitrones with -allyl--benzylquinazoline-2,4-diones produced mixtures of diastereoisomeric 3-(diethoxyphosphonyl)isoxazolidines with a -benzylquinazoline-2,4-dione unit at C5. The obtained compounds were assessed for antiviral and antibacterial activities. Several compounds showed moderate inhibitory activities against VZV with EC values in the range of 12.
View Article and Find Full Text PDFCycloadditions of N-substituted C-(diethoxyphosphoryl)nitrones to N-allylated quinazoline-2,4-diones functionalized at N3 with substituted benzoyl or benzyl groups proceeded with moderate to good diastereoselectivities (d.e. 28-68%).
View Article and Find Full Text PDFModerate diastereoselectivities (d.e. 2-62%) of isoxazolidine homonucleotides were observed for cycloadditions between N-methyl-C-(diethoxyphosphoryl)nitrone and N-allyl nucleobases, with trans-isoxazolidines predominating.
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January 2013
Properties of acoustic plate modes (APMs) in YZ LiNbO₃ were calculated and measured. It was found that these modes have a dominant longitudinal component of mechanical motion concentrated near both surfaces of a plate. A delay line with double-electrode interdigital transducers (IDTs) was used for the measurements.
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November 2011
Mass density, dielectric, elastic, and piezoelectric constants of bulk GaN crystal were determined. Mass density was obtained from the measured ratio of mass to volume of a cuboid. The dielectric constants were determined from the measured capacitances of an interdigital transducer (IDT) deposited on a Z-cut plate and from a parallel plate capacitor fabricated from this plate.
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October 2011
Properties of shear horizontal acoustic plate modes (SHAPMs) in BT-cut quartz were calculated and measured. A delay line with a long interdigital transducer, deposited on -50.5°YX90°-oriented quartz plate, was used for the measurements.
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