Publications by authors named "Magdalena Kwasniak-Butowska"
Article Synopsis
- Parkinson's disease (PD) is a neurodegenerative condition with both motor and non-motor symptoms, including dementia and cognitive impairment, and its causes and risk factors are not yet fully understood.
- Research has linked specific genetic variations (SNPs) in the HMGCR gene, which is involved in cholesterol synthesis, to PD susceptibility and cognitive decline in patients.
- The study found that certain genetic variants were associated with high-density lipoprotein (HDL) levels in PD patients but did not establish a significant link between these SNPs and cognitive status; further research with larger samples is needed.
The prevalence of neurodegenerative diseases (NDs) is increasing due to the aging population and improved longevity. They are characterized by a range of pathological hallmarks, including protein aggregation, mitochondrial dysfunction, and oxidative stress. The aim of this review is to summarize the alterations in brain energy and amino acid metabolism in Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD).
View Article and Find Full Text PDFBackground: After more than 2 years of the pandemic, effective treatment for COVID-19 is still under research. In recent months, publications hypothesized amantadine's potential beneficial effect on SARS-CoV-2 infection.
Objective: To compare the groups of Parkinson's Disease (PD) patients who were administered amantadine chronically and those who did not take this medication in the context of the incidence and severity of COVID-19 infection.
Dementia in advanced Parkinson's Disease (PD) is a fatal milestone resulting in reduced life expectancy and nursing home placement. Cognitive impairment and cardiovascular dysautonomia are common and debilitating non-motor symptoms that frequently coexist in PD since the early stages and progress in subsequent years. In particular, blood pressure (BP) abnormalities, including orthostatic hypotension (OH), supine hypertension (SH) and the loss of nocturnal BP fall (non-dipping) in PD have been associated with cognitive deterioration.
View Article and Find Full Text PDFDementia is one of the most disabling non-motor symptoms in Parkinson's disease (PD). Unlike in Alzheimer's disease, the vascular pathology in PD is less documented. Due to the uncertain role of commonly investigated metabolic or vascular factors, e.
View Article and Find Full Text PDFIntroduction: Huntington's Disease (HD) is a neurodegenerative disorder of which the main symptoms are motor, cognitive and behavioural problems sometimes including sexual dysfunction.
Aim: To review the current knowledge on sexual dysfunction in HD.
Methods: Databases of Pubmed and Scopus were searched.