Publications by authors named "Magdalena Kocur"
IFNβ secreted by microglia mediates clearance of myelin debris in CNS autoimmunity.
Acta Neuropathol Commun
April 2015
Article Synopsis
- Multiple sclerosis (MS) is a progressive condition that damages the central nervous system and interferon β (IFNβ) is an important treatment for relapsing forms of the disease.
- Research revealed that a specific group of activated microglia are the main producers of IFNβ during disease peak, and they are found in areas of active damage associated with myelin loss.
- The study shows that IFNβ enhances microglia's ability to clean up myelin debris, suggesting these immune cells play a crucial role in both producing IFNβ and promoting myelin clearance in MS.
Production of type I interferons, consisting mainly of multiple IFNα subtypes and IFNβ, represents an essential part of the innate immune defense against invading pathogens. While in most situations, namely viral infections, this class of cytokines is indispensable for host survival they mediate a detrimental effect during infection with L. monocytogenes by rendering macrophages insensitive towards IFNγ signalling which leads to a lethal bacterial pathology in mice.
View Article and Find Full Text PDFAfter birth, the intestinal mucosa undergoes a dramatic transition from a sterile protected site to an environmentally exposed and permanently colonized surface. The mechanisms that facilitate this transition are ill defined. Here, we demonstrate that microRNA-146a-mediated translational repression and proteolytic degradation of the essential Toll-like receptor (TLR) signaling molecule interleukin 1 receptor associated kinase 1 (IRAK1) is sufficient to induce intestinal epithelial innate immune tolerance and provide protection from bacteria-induced epithelial damage in neonates.
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