Oxygenated Hydrogel Promotes Re-Epithelialization and Reduces Inflammation in a Perturbed Wound Model in Rat.

Chronic wounds can take months or even years to heal and require proper medical intervention. Normal wound healing processes require adequate oxygen supply. Accordingly, destroyed or inefficient vasculature leads to insufficient delivery to peripheral tissues and impair healing.

Fecal microbiota profiles in treatment-naïve pediatric inflammatory bowel disease - associations with disease phenotype, treatment, and outcome.

Purpose: Imbalance in the microbiota, dysbiosis, has been identified in inflammatory bowel disease (IBD). We explored the fecal microbiota in pediatric patients with treatment-naïve IBD, non-IBD patients with gastrointestinal symptoms and healthy children, its relation to IBD subgroups, and treatment outcomes.

Patients And Methods: Fecal samples were collected from 235 children below 18 years of age.

Bead-beating artefacts in the Bacteroidetes to Firmicutes ratio of the human stool metagenome.

We evaluated bead-beating cell-lysis in analysing the human stool metagenome, since this is a key step. We observed that two different bead-beating instruments from the same producer gave a three-fold difference in the Bacteroidetes to Firmicutes ratio. This illustrates that bead-beating can have a major impact on downstream metagenome analyses.

Meanings of existential uncertainty and certainty for people diagnosed with cancer and receiving palliative treatment: a life-world phenomenological study.

Background: Many people around the world are getting cancer and living longer with the disease. Thanks to improved treatment options in healthcare, patients diagnosed with advanced gastrointestinal cancer can increasingly live for longer. Living with cancer creates existential uncertainty, but what does this situation mean for the individual? The purpose of the study is to interpret meanings of existential uncertainty and certainty for people diagnosed with advanced gastrointestinal cancer and receiving palliative treatment.

Found in transcription: accurate Parkinson's disease classification in peripheral blood.

Background: A blood-based test for the early detection of Parkinson's disease (PD) would be an important diagnostic tool and useful for patient selection when developing novel drugs or treatments for the disease.

Objective: Here, we aimed to identify potential biomarkers associated with PD.

Methods: We applied gene expression profiling to the study of peripheral blood from 75 healthy control subjects and 79 PD patients at different stages of the disease.

Microarray-based prediction of Parkinson's disease using clinical data as additional response variables.

Recent discoveries and developments in the field of genomics have led to the commercialization of novel diagnostic devices for studying disease or estimating therapeutic outcomes in individual patients. With this emerging field, the emphasis is shifting to integration of clinical research into product development. Data acquisition is primary in the initial exploratory phase of product development, and during the process of sample collection and data generation in clinical microarray studies, great amounts of additional information, such as demographic, clinical, and study design variables associated with the data, are often accumulated and made available.