Publications by authors named "Magdalena Karlikowska"
In June 2021, a national incident team was formed due to an increased detection of in samples from hospitalised infants. has been known to cause outbreaks in neonatal units across the globe, but the extent of the UK spread was unclear. A literature review was undertaken to support case identification, clinical management and environmental infection control.
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- The intracellular human pathogen, referred to as (), has adapted to thrive in nutrient-poor environments within its host for extended periods.
- The UspABC transporter system is crucial for importing essential nutrients, yet its specific functions and substrate preferences are not well understood.
- Research using mutant strains has revealed that UspABC significantly influences carbon utilization and metabolic pathways related to sugar and lipid metabolism, which are vital for cell envelope synthesis.
Background: The largest outbreak of isoniazid-resistant (INH-R) Mycobacterium tuberculosis in Western Europe is centred in North London, with over 400 cases diagnosed since 1995. In the current study, we evaluated the genetic variation in a subset of clinical samples from the outbreak with the hypothesis that these isolates have unique biological characteristics that have served to prolong the outbreak.
Methods: Fitness assays, mutation rate estimation, and whole-genome sequencing were performed to test for selective advantage and compensatory mutations.