Publications by authors named "Magdalena Fritz"
Storage of packed red blood cells is associated with changes in erythrocytes that over time increasingly impair cellular function and potentially contribute to adverse effects associated with blood transfusion. Exposure of phosphatidylserine at the outer membrane leaflet of erythrocytes and shedding of microvesicles (MVs) during packed red blood cell storage are alterations assumed to increase the risk of prothrombotic events in recipients. Here, we used rotational thromboelastometry to study the coagulation process in blood samples with erythrocytes from stored PRBCs reconstituted with freshly prepared platelet-rich plasma.
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- Ascorbic acid (AA), or vitamin C, is crucial for certain mammals that cannot produce it themselves, relying instead on their diet for this antioxidant.
- Human red blood cells express the GLUT1 transporter, which allows for quick uptake of glucose and dehydroascorbate (DHA), an oxidized form of AA, enhancing cellular functions like reducing oxidized species.
- The study findings suggest that DHA uptake not only improves the redox balance by decreasing harmful free radicals but also supports the recycling of AA, hinting at evolutionary adaptations in mammals that cannot synthesize AA.
Recent studies indicate that erythrocytes actively modulate blood clotting and thrombus formation. The lipid mediator lysophosphatidic acid (LPA) is produced by activated platelets, and triggers a signaling process in erythrocytes. This results in cellular calcium uptake and exposure of phosphatidylserine (PS) at the cell surface, thereby generating activated membrane binding sites for factors of the clotting cascade.
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