Publications by authors named "Magdalena Fandino-Del-Rio"

Article Synopsis
  • Pesticides, particularly chlorpyrifos, may negatively affect respiratory health and contribute to asthma symptoms among low-income, Black children in Baltimore City, with limited existing research on this issue.
  • A study involving 148 children with asthma measured various pesticide biomarker concentrations in their urine over a year, linking higher levels of specific biomarkers to increased asthma-related symptoms and healthcare needs.
  • Findings indicated that exposure to higher levels of chlorpyrifos (TCPY) was significantly associated with worsened asthma symptoms, including increased coughing, wheezing, and chest tightness, suggesting a potential harmful impact of these pesticides on pediatric respiratory health.
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  • Emerging research indicates that endocrine disrupting chemicals (EDCs) found in personal care products can negatively impact health, particularly for Black individuals who use more products and have high asthma rates.
  • This study investigates the link between EDC exposure and product usage in 110 Black children with asthma, aged 8-17, in Baltimore City, examining their recent consumer habits and urine concentrations of specific EDCs.
  • Results show that using air fresheners, scented candles, and canned foods is associated with higher levels of certain EDCs, highlighting a potential risk factor for these children’s health.
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  • The study assessed whether providing 12 months of free liquefied petroleum gas (LPG) and behavioral support would encourage continued use and purchase after the free period ended.
  • 180 women participated, with half receiving free LPG while the other half served as a control group; measurements included stove usage and in-depth interviews to assess behavior change.
  • Results showed that the intervention group sustained high LPG usage (85.4% of days) post-free fuel period, but continued use was influenced by affordability, cooking habits, and access to LPG delivery services.
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Objective: Household air pollution (HAP) is a widespread environmental exposure worldwide. While several cleaner fuel interventions have been implemented to reduce personal exposures to HAP, it is unclear if cooking with cleaner fuels also affects the choice of meals and dietary intake.

Design: Individually randomised, open-label controlled trial of a HAP intervention.

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Low-wage service sector jobs are largely occupied by racial/ethnic minority workers who often experience an increased risk of elevated chemical exposures, including chemicals like phthalates, compared to the general public. Phthalates have been linked with adverse health effects, including increased risk of atopy and asthma. An important etiological component in respiratory disease, including asthma, is the role of the upper respiratory microbiota in atopic disease development.

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Salon workers, especially those serving an ethnically and racially diverse clientele (i.e., Black/Latina), may experience disparately high levels of workplace exposures to respiratory irritants, including volatile organic compounds (VOCs).

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Background: Household air pollution (HAP) from biomass fuel combustion remains a leading environmental risk factor for morbidity worldwide.

Objective: Measure the effect of liquefied petroleum gas (LPG) interventions on HAP exposures in Puno, Peru.

Methods: We conducted a 1-y randomized controlled trial followed by a 1-y pragmatic crossover trial in 180 women age 25-64 y.

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Background: Phthalates are synthetic chemicals present in building materials, personal care products and other consumer goods. Limited studies link phthalates to pediatric asthma incidence; however, their effects on respiratory-related outcomes among those with pre-existing asthma remains unclear.

Objective: We examined associations between phthalates and asthma symptoms, healthcare use, lung function, and lung inflammation among children with asthma.

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Household air pollution (HAP) from biomass stoves is a leading risk factor for cardiopulmonary outcomes; however, its toxicity pathways and relationship with inflammation markers are poorly understood. Among 180 adult women in rural Peru, we examined the cross-sectional exposure-response relationship between biomass HAP and markers of inflammation in blood using baseline measurements from a randomized trial. We measured markers of inflammation (CRP, IL-6, IL-10, IL-1β, and TNF-α) with dried blood spots, 48-h kitchen area concentrations and personal exposures to fine particulate matter (PM ), black carbon (BC), and carbon monoxide (CO), and 48-h kitchen concentrations of nitrogen dioxide (NO ) in a subset of 97 participants.

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Reducing the burden of household air pollution could be achieved with exclusive adoption of cleaner fuels such as liquefied petroleum gas (LPG). However, we lack understanding of how much LPG is required to support exclusive use and how household characteristics affect this quantity. This paper used data from 90 participants in the Cardiopulmonary outcomes and Household Air Pollution (CHAP) trial in Puno, Peru who received free LPG deliveries for one year.

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Approximately 40% of people worldwide are exposed to household air pollution (HAP) from the burning of biomass fuels. Previous efforts to document health benefits of HAP mitigation have been stymied by an inability to lower emissions to target levels. We sought to determine if a household air pollution intervention with liquefied petroleum gas (LPG) improved cardiopulmonary health outcomes in adult women living in a resource-poor setting in Peru.

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Background: Liquefied petroleum gas (LPG) stoves have been promoted in low- and middle-income countries (LMICs) as a clean energy alternative to biomass burning cookstoves.

Objective: We sought to characterize kitchen area concentrations and personal exposures to nitrogen dioxide (NO) within a randomized controlled trial in the Peruvian Andes. The intervention included the provision of an LPG stove and continuous fuel distribution with behavioral messaging to maximize compliance.

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Background: Efforts to promote clean cooking through adoption of clean-burning fuels such as liquefied petroleum gas (LPG) are often based on the idea that near-exclusive use of LPG could lead to health improvements. However, benefits beyond health, such as time savings, could be more tangible and meaningful to LPG users.

Objectives: This study investigated the effect of an LPG intervention on time spent cooking and collecting fuel, using objective measures of stove temperatures combined with self-reports under conditions of near-exclusive LPG use.

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Background: Household air pollution (HAP) from combustion of biomass fuel, such as wood and animal dung, is among the leading environmental risk factors for preventable disease. Close to half of the world's population relies on biomass cookstoves for their daily cooking needs. Understanding factors that affect HAP can inform measures to maximize the effectiveness of cookstove interventions in a cost-effective manner.

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Reducing the burden of household air pollution requires that cleaner fuels such as liquefied petroleum gas (LPG) be used nearly exclusively. However, exclusive adoption has been challenging in low- and middle-income countries. Previous studies have found that economic, social, and cultural barriers often impede adoption.

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Exposure to high concentrations of particulate matter (PM) is associated with a number of adverse health effects. However, it is unclear which aspects of PM are most hazardous, and a better understanding of particle sizes and personal exposure is needed. We characterized particle size distribution (PSD) from biomass-related pollution and assessed total and regional lung-deposited doses using multiple-path deposition modeling.

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Background: Indoor air pollution is an important risk factor for health in low- and middle-income countries.

Methods: We measured indoor fine particulate matter (PM) and carbon monoxide (CO) concentrations in 617 houses across four settings with varying urbanisation, altitude, and biomass cookstove use in Peru, between 2010 and 2016. We assessed the associations between indoor pollutant concentrations and blood pressure (BP), exhaled carbon monoxide (eCO), C-reactive protein (CRP), and haemoglobin A1c (HbA1c) using multivariable linear regression among all participants and stratifying by use of biomass cookstoves.

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Background: Household air pollution from biomass cookstoves is a major contributor to global morbidity and mortality, yet little is known about exposures to nitrogen dioxide (NO ).

Objective: To characterize NO kitchen area concentrations and personal exposures among women with biomass cookstoves in the Peruvian Andes.

Methods: We measured kitchen area NO concentrations at high-temporal resolution in 100 homes in the Peruvian Andes.

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Assessment of personal exposure to PM is critical for understanding intervention effectiveness and exposure-response relationships in household air pollution studies. In this pilot study, we compared PM concentrations obtained from two next-generation personal exposure monitors (the Enhanced Children MicroPEM or ECM; and the Ultrasonic Personal Air Sampler or UPAS) to those obtained with a traditional Triplex Cyclone and SKC Air Pump (a gravimetric cyclone/pump sampler). We co-located cyclone/pumps with an ECM and UPAS to obtain 24-hour kitchen concentrations and personal exposure measurements.

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Introduction: Over 80% of rural households in Peru use solid fuels as their primary source of domestic energy, which contributes to several health problems. In 2016, 6.7 million Peruvians were living in rural areas.

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Background: Biomass fuel smoke is a leading risk factor for the burden of disease worldwide. International campaigns are promoting the widespread adoption of liquefied petroleum gas (LPG) in resource-limited settings. However, it is unclear if the introduction and use of LPG stoves, in settings where biomass fuels are used daily, reduces pollution concentration exposure, improves health outcomes, or how cultural and social barriers influence the exclusive adoption of LPG stoves.

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