Publications by authors named "Magdalena Drotarova"
Human ARMC6 binds in vitro to both cancer genes and telomeric RNA, favoring G-quadruplex structure recognition.
Biochim Biophys Acta Gene Regul Mech
September 2024
Article Synopsis
- Armadillo repeat-containing proteins (ARMCs) are important for various cellular functions like adhesion, signaling, and regulating cellular structures, with ARMC6 being significant in primates but its specific roles were previously unclear.
- Recent experiments show that ARMC6 binds to DNA promoter sequences of cancer-related genes and to telomeric RNA, suggesting involvement in chromosomal maintenance via recognition of G-quadruplex structures.
- Overexpression of ARMC6 in human cell lines leads to altered expression of oncogenic and telomerase-related genes, highlighting its potential role in linking gene regulation with telomeric chromatin rearrangement.